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方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 10 mg/mL, clear
储存温度
2-8°C
SMILES字符串
Fc1ccc(cc1)C(=O)Nc2cc3c([nH]c4c3C[C@@H](CC4)N(C)C)cc2.Cl
InChI
1S/C21H22FN3O.ClH/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13;/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26);1H/t16-;/m1./s1
InChI key
OKUHLSYESBLBCP-PKLMIRHRSA-N
生化/生理作用
LY344864 hydrochloride is a potent and selective 5-HT1F receptor agonist.
LY344864 hydrochloride is a potent and selective 5-HT1F receptor agonist. It has an EC50 of 3 nM, and displays > 80-fold selectivity over other 5-HT receptors
LY344864 might be useful in the treatment approach for migraine. LY344864 is found to prevent the extravasation of dura protein and reduce c-fos like immunoreactions induced by capsaicin.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
5HT1F-and 5HT7-receptor agonists for the treatment of migraines.
Agosti R M.
CNS & Neurological Disorders Drug Targets, 6(4), 235-237 (2007)
Hans Jürgen Solinski et al.
Cell reports, 26(13), 3561-3573 (2019-03-28)
Itch is an unpleasant skin sensation that can be triggered by exposure to many chemicals, including those released by mast cells. The natriuretic polypeptide b (Nppb)-expressing class of sensory neurons, when activated, elicits scratching responses in mice, but it is
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