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Merck
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文件

SML0095

Sigma-Aldrich

Conessine

≥97% (HPLC)

别名:

(3β)-N,N-dimethyl-con-5-enin-3-amine, Conessin, NSC 119994, Neriine, Roquessine, Wrightine

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About This Item

经验公式（希尔记法）:
C24H40N2
CAS号:
546-06-5
分子量:
356.59
EC號碼:
208-897-2
MDL號碼:
MFCD00016752
分類程式碼代碼:
12352200
PubChem物質ID:
329825153
NACRES:
NA.77

化驗

≥97% (HPLC)

形狀

powder

顏色

white to tan

溶解度

ethanol: ≥2 mg/mL

起源

Abbott

儲存溫度

2-8°C

SMILES 字串

C[C@H]1[C@H]2CC[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23CN1C)N(C)C

InChI

1S/C24H40N2/c1-16-20-8-9-22-19-7-6-17-14-18(25(3)4)10-12-23(17,2)21(19)11-13-24(20,22)15-26(16)5/h6,16,18-22H,7-15H2,1-5H3/t16-,18-,19+,20+,21-,22-,23-,24-/m0/s1

InChI 密鑰

GPLGAQQQNWMVMM-MYAJQUOBSA-N

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一般說明

Conessine is a steroidal alkaloid. It has anti-malarial properties, thus, conessine has been used in treatment of malaria.

生化／生理作用

Conessine is a plant steroid alkaloid that acts as a potent and specific antagonist of histamine H3 receptors (Ki = 5.37 and 24.5 nM for human and rat receptors, respectively). Conessine is 1860-fold selective for H3 over H4 and does not bind to H1 or H2 receptors. The molecule also binds to the human α2C4 adrenergic receptor (pKi = 7.98).

特點和優勢

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319,H335

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

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[Aminohydroxyconessine dihydrobromide in therapy of intestinal or hepatic amebiasis; results obtained].
R CROSNIER et al.
La Semana medica, 28(45), 850-852 (1952-12-22)
A new family of histamine H3 receptor antagonists based on a natural product: discovery, SAR, and properties of the series.
M Cowart et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 56 Suppl 1, S47-S48 (2007-09-07)
[Experimental studies of conessine. Comparative study of the culture medium of dysenteric amoeba after addition of chlorhydrates of conessine or emetine].
M PIETTE
Annales pharmaceutiques francaises, 8(5), 402-409 (1950-05-01)
[Distribution and fixation time of conessine in the organs of the monkey].
C AUFFRET et al.
Medecine tropicale : revue du Corps de sante colonial, 10(3), 530-536 (1950-05-01)
[Conessine in the treatment of vaginitis due to Trichomonas].
A SICARD et al.
La Presse medicale, 58(48), 853-853 (1950-07-29)
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