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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to tan
溶解度
DMSO: ≥5 mg/mL
應用
agriculture
儲存溫度
2-8°C
SMILES 字串
OC(=O)CCC(=O)Nc1ccc(Br)cn1
InChI
1S/C9H9BrN2O3/c10-6-1-2-7(11-5-6)12-8(13)3-4-9(14)15/h1-2,5H,3-4H2,(H,14,15)(H,11,12,13)
InChI 密鑰
XFYYQDHEDOXWGA-UHFFFAOYSA-N
應用
Bikinin 已被用于:
- 作为拟南芥 Col-0 幼苗中的糖原合酶激酶 3（GSK3）抑制剂，用于测试其对基因表达的影响
- 作为诱导培养基的成分和 GSK3 抑制剂，用于测试其对拟南芥叶盘或子叶中叶肉细胞的影响
- 作为油菜素内酯激动剂，用于测试其对毛柄水毛茛陆地叶指数的影响
生化／生理作用
Bikinin是一种油菜素类固醇（BR）信号转导的强激活剂。它是拟南芥GSK-3抑制剂、拟南芥SHAGGY相关激酶抑制剂、以及GSK-3样激酶BIN2抑制剂。Bikinin可通过干扰ATP结合直接抑制BIN2（II类GSK3s）。 Bikinin对拟南芥GSK3激酶的亚类（包括BIN2和ASKα 、γ 、ε、ι,和θ）具有特异性。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
Wei Lin et al.
Science advances, 6(26), eaaz2963-eaaz2963 (2020-07-09)
DNA demethylation is important for the erasure of DNA methylation. The role of DNA demethylation in plant development remains poorly understood. Here, we found extensive DNA demethylation in the CHH context around pericentromeric regions and DNA demethylation in the CG
Yunshuai Huang et al.
Journal of integrative plant biology, 64(10), 1883-1900 (2022-07-30)
Grain size is a key agronomic trait that determines the yield in plants. Regulation of grain size by brassinosteroids (BRs) in rice has been widely reported. However, the relationship between the BR signaling pathway and grain size still requires further
Bert De Rybel et al.
Chemistry & biology, 16(6), 594-604 (2009-06-25)
Glycogen synthase kinase 3 (GSK3) is a key regulator in signaling pathways in both animals and plants. Three Arabidopsis thaliana GSK3s are shown to be related to brassinosteroid (BR) signaling. In a phenotype-based compound screen we identified bikinin, a small
Juhyun Kim et al.
PLoS genetics, 14(2), e1007208-e1007208 (2018-02-16)
Ranunculus trichophyllus is an amphibious plant that produces thin and cylindrical leaves if grown under water but thick and broad leaves if grown on land. We found that such heterophylly is widely controlled by two plant hormones, abscisic acid (ABA)
Structure-function study of a novel inhibitor of the casein kinase 1 family in Arabidopsis thaliana.
Ami N Saito et al.
Plant direct, 3(9), e00172-e00172 (2019-09-25)
Casein kinase 1 (CK1) is an evolutionarily conserved protein kinase family among eukaryotes. Studies in non-plants have shown CK1-dependent divergent biological processes, but the collective knowledge regarding the biological roles of plant CK1 lags far behind other members of the
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