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Merck
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文件

SML0077

Sigma-Aldrich

VU591

≥98% (HPLC)

别名:

2,2′-(oxydimethanediyl)bis(5-nitro-1H-benzimidazole), 2,2′-(oxydimethanediyl)bis(6-nitro-1H-benzimidazole), 5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole

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About This Item

经验公式（希尔记法）:
C16H12N6O5
CAS号:
1222810-74-3
分子量:
368.30
分類程式碼代碼:
12352200
PubChem物質ID:
329825139
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to tan

溶解度

DMSO: ≥12 mg/mL

儲存溫度

2-8°C

SMILES 字串

[O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1

InChI

1S/C16H12N6O5/c23-21(24)9-1-3-11-13(5-9)19-15(17-11)7-27-8-16-18-12-4-2-10(22(25)26)6-14(12)20-16/h1-6H,7-8H2,(H,17,19)(H,18,20)

InChI 密鑰

ZQPXNYLXYNRFNP-UHFFFAOYSA-N

基因資訊

human ... KCNJ1(3758)

應用

VU591 may be used in cell signaling studies.

生化／生理作用

VU591 is a Potassium Inwardly-Rectifying Channel (KCNJ1 or ROMK) specific inhibitor (IC50 = 240 nM) that is closely related to VU590. Unlike VU590, VU591 does not inhibit Kir7.1. The compound has a modest effect on Kir6.2/SUR1, causing 17% inhibition at 10 uM.

特點和優勢

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Jiun-Lin Horng et al.
Scientific reports, 7(1), 16215-16215 (2017-11-28)
Molecular mechanisms of Na
Guglielmo Schiano et al.
Scientific reports, 9(1), 19517-19517 (2019-12-22)
Uromodulin, the most abundant protein in normal urine, is produced by cells lining the thick ascending limb (TAL) of the loop of Henle. Uromodulin regulates the activity of the potassium channel ROMK in TAL cells. Common variants in KCNJ1, the

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