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SMB00607

Sigma-Aldrich

阿莫西林三水合物:克拉维酸钾(4:1)

别名:

阿莫西林三水合物:克拉维酸钾

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1 G
$327.00

$327.00


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1 G
$327.00

About This Item

UNSPSC代码:
51285005
NACRES:
NA.85

$327.00


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表单

powder

质量水平

储存条件

(Keep container tightly closed in a dry and well-ventilated place. Never allow produc to get in contact with water during storage.)

颜色

white to yellow

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

cell wall synthesis | interferes

储存温度

2-8°C

一般描述

阿莫西林三水合物是一种可用作药物的半合成抗生素。[1]

应用

阿莫西林三水合物:克拉维酸钾(4:1)已被用于研究其对小鼠模型中病毒性déjà vu疾病(新生儿脑内(i.c.)感染)的影响。[2]

生化/生理作用

阿莫西林三水合物是一种广谱的β-内酰胺抗生素。它可抑制线性肽聚糖聚合物链之间的交联,而线性肽聚糖聚合物链是革兰氏阳性菌和革兰氏阴性菌的主要成分。[3][4]由于阿莫西林可被β-内酰胺酶降解,因此它对产生这些酶的细菌没有活性。

克拉维酸是一种与青霉素相关的β-内酰胺抗生素。克拉维酸能够竞争性且不可逆地抑制在青霉素和头孢菌素抗性细菌中发现的多种β-内酰胺酶[5][6]

阿莫西林与克拉维酸组成的制剂可防止β-内酰胺酶降解阿莫西林。这提高了阿莫西林针对通常具有β-内酰胺抗生素抗性细菌的抗菌活性。[7]

包装

1G

组分

材料是4份阿莫西林三水合物与1份克拉维酸钾的粉末混合物。

储存及稳定性

保存于密闭容器内,置于干燥通风处。禁止让产品在储存期间与水接触。

其他说明

将容器密闭保存在干燥和通风良好的地方。禁止让产品在储存期间与水发生接触。

象形图

FlameHealth hazard

警示用语:

Danger

危险分类

Flam. Sol. 2 - Resp. Sens. 1 - Self-heat. 2 - Skin Sens. 1

补充剂危害

储存分类代码

4.2 - Pyrophoric and self-heating hazardous materials

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping
Di Liberto G, et al.
Cell (2018)
Preparation and characterization of Sn/Zn/TiO2 photocatalyst for enhanced amoxicillin trihydrate degradation
Mohammadi R, et al.
Desalination and Water Treatment, 53(7), 1995-2004 (2015)
R N Brogden et al.
Drugs, 18(3), 169-184 (1979-09-01)
Amoxycillin, an acid stable semisynthetic penicillin shown to be effective against a wide range of infections when given orally, is now available for intramuscular and intravenous injection. Amoxycillin has an antibacterial spectrum and level of activity essentially the same as
In vitro antimicrobial activity of 6(D(-) -amino-p-hydroxyphenylacetamido) penicillanic acid, a new semisynthetic penicillin.
H C Neu et al.
Antimicrobial agents and chemotherapy, 10, 407-410 (1970-01-01)
A P Ball et al.
Lancet (London, England), 1(8169), 620-623 (1980-03-22)
Clavulanic acid is an inhibitor of certain beta-lactamases, notably those enzymes which inactivate the penicillins and cause resistance of important bacteria to these antibiotics. Microbiological, pharmacological, and clinical studies show that clavulanic acid in combination with amoxycillin is effective and

Questions

  1. What are the uses and potential reactions of Amoxicillin and Clavulanate Potassium

    1 answer
    1. This product is supplied for research purposes with the primary use as an antibiotic. Formulations of amoxicillin with clavulanic acid prevent the degradation of amoxicillin by β-lactamase enzymes. This increases amoxicillin's antibacterial activity against bacteria normally resistant to β-lactam antibiotics. Please see the peer-reviewed paper section in the link below for potential use information.

      https://www.sigmaaldrich.com/search/smb00607?focus=papers&page=1&perpage=30&sort=relevance&term=SMB00607&type=citation_search

      Products are not tested for safety and efficacy in food, drug, medical device, cosmetic, commercial, or any other use. Potential reactions or side effects are not evaluated.

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