SBR00037

Solithromycin

≥98% (HPLC)

• 别名: 2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, CEM-101, OP-1068
• 经验公式（希尔记法）: C₄₃H₆₅FN₆O₁₀
• 分子量: 845.01
• MDL编号: MFCD30207880
• UNSPSC代码: 51102829
• NACRES: NA.76

属性

• 质量水平: 200
• 方案: ≥98% (HPLC)
• 表单: powder
• 颜色: white to off-white
• 抗生素抗菌谱: Gram-negative bacteria; Gram-positive bacteria
• 作用机制: protein synthesis | interferes
• 储存温度: −20°C
• SMILES字符串: F[C@@]1(C(=O)O[C@@H]([C@]2(OC(=O)N([C@@H]2[C@H](C(=O)[C@@H](C[C@]([C@@H]([C@H](C1=O)C)O[C@@H]5O[C@@H](C[C@@H]([C@H]5O)N(C)C)C)(OC)C)C)C)CCCC[n]3nnc(c3)c4cc(ccc4)N)C)CC)C
• InChI: 1S/C43H65FN6O10/c1-12-32-43(8)35(50(40(55)60-43)19-14-13-18-49-23-30(46-47-49)28-16-15-17-29(45)21-28)26(4)33(51)24(2)22-41(6,56-11)37(27(5)36(53)42(7,44)39(54)58-32)59-38-34(52)31(48(9)10)20-25(3)57-38/h15-17,21,23-27,31-32,34-35,37-38,52H,12-14,18-20,22,45H2,1-11H3/t24-,25-,26+,27+,31+,32-,34-,35-,37-,38+,41-,42+,43-/m1/s1
• InChI key: IXXFZUPTQVDPPK-ZAWHAJPISA-N

说明

一般描述

Solithromycin is a highly potent next-generation macrolid. the first fluoroketolid. which has potent activity against most macrolide-resistant strains. Solithromycin (CEM-101) is a novel fluoroketolide with improved antimicrobial effectiveness.

应用

Solithromycin has been shown to have potentent activity against S. pneumoniae as well as an extended spectrum of activity against CA-MRS. enterococc according to in vitro and in vivo research. Solithromycin has been used in:

• the research on the anti-inflammatory effects of macrolides[1]
• the research of potency of solithromycin in comparison to other antimicrobials[2]
• in ithe research of the vitro activity of solithromycin against clinical N. gonorrhoeae isolates and reference strain[3]

生化/生理作用

Mode of Action: Solithromycin binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis. Like other ketolide. it should impair bacterial ribosomal subunit formation.

Antimicrobial spectrum: Active against bacteria like Legionella, Chlamydophila, Chlamydia, Mycoplasma, and Ureaplasma and against gonococci and other organisms that cause genitourinary tract infections

特点和优势

High quality antibiotic suitable for mulitple research applications

其他说明

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安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable