$499.00
预计发货时间2025年7月17日详情
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生物来源
rabbit
质量水平
重组
expressed in proprietary host
偶联物
unconjugated
抗体形式
tissue culture supernatant
抗体产品类型
primary antibodies
克隆
SP6, monoclonal
种属反应性
human (tested)
种属反应性（根据同源性预测）
bovine
技术
immunohistochemistry: 1:200
同位素/亚型
IgG
UniProt登记号
运输
wet ice
储存温度
2-8°C
靶向翻译后修饰
unmodified
基因信息
human ... MKI67(4288)
一般描述
Ki-67 is a nuclear protein, which is expressed in the proliferating cells. Ki-67 is preferentially expressed during late G1-, S-, M-, and G2-phases of the cell cycle, while cells in the G0 (quiescent) phase are negative for this protein.
The gene marker of proliferation Ki-67 (MKI67), spanning 15 exons, is mapped to human chromosome 10q26.2. The encoded protein contains phosphopeptide-binding forkhead-associated (FHA) domain and a protein phosphatase 1 (PP1)-binding site at N- terminal. It possesses 16 tandem repeats at central region and leucine and arginine (LR) pairs at C- terminal end.
免疫原
Synthetic peptide from C-terminus of human Ki-67 protein.
应用
Anti-KI-67 antibody, Rabbit monoclonal has been used in immunohistochemistry.
生化/生理作用
Marker of proliferation Ki-67 (MKI67), which is a part of the mitotic chromosome periphery, functions as a biological surfactant to maintain individual mitotic chromosomes dispersed in the cytoplasm after nuclear envelope disassembly. Ki-67 is a vital prognostic marker in breast and prostate cancer. Expression of the encoded protein is associated with cell-proliferation rate. Ki-67 is expressed at all active phases of the cell cycle (G (1), S, G (2), and mitosis), except resting cells (G (0)). Therefore, this protein is considered to be a potent cell proliferation marker.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
0.1 ml rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Ki-67 is a prognostic parameter in breast cancer patients: results of a large population-based cohort of a cancer registry.
Inwald E C, et al.
Breast Cancer Research and Treatment, 139(2), 539-552 (2013)
The Ki?67 protein: from the known and the unknown.
Scholzen T and Johannes G
Journal of Cellular Physiology, 182(3), 311-322 (2000)
Ki67 labelling index: an independent predictor of progression in prostate cancer treated by radical prostatectomy.
Bubendrof L, et al.
The Journal of Pathology, 178(4), 437-441 (1996)
Veronique L Veenstra et al.
Molecular oncology, 11(8), 1050-1064 (2017-05-10)
Pancreatic ductal adenocarcinoma (PDAC) is marked by an abundant stromal deposition. This stroma is suspected to harbor both tumor-promoting and tumor-suppressing properties. This is underscored by the disappointing results of stroma targeting in clinical studies. Given the complexity of tumor-stroma
Ki-67 antigen in lung neuroendocrine tumors: unraveling a role in clinical practice.
Pelosi G, et al.
Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 9(3), 273-284 (2014)
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