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生物来源
mouse
偶联物
biotin conjugate
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
DC-10, monoclonal
表单
buffered aqueous solution
种属反应性
human
浓度
1 mg/mL
技术
flow cytometry: suitable
同位素/亚型
IgG1
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
2-8°C
靶向翻译后修饰
unmodified
基因信息
human ... KRT18(3875)
一般描述
Keratin 18 (KRT 18) or cytokeratin 18 (CK18) encodes the type I intermediate filament chain keratin 18. The antibody DC-10 reacts with Cytokeratin 18 (45 kDa). Cytokeratins are a member of intermediate filaments subfamily represented in epithelial tissues. In human chromosome, the gene KRT18 is localized on 12q13.13.
免疫原
Human breast carcinoma cell line PMC-42
应用
The reagent is designed for Flow Cytometry. Suggested working dilution is 1:500. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
生化/生理作用
Keratin 18 (KRT18/CK18) pairs with CK8 to form the intermediate filaments and maintain the integrity in hepatocytes. CK18 associates with histone H3 in the progression of hepatocellular carcinoma (HCC). Disorganization or altered levels of CK18 is related to plectin deficiency in HCC. K18 may be a marker for liver diseases. K18 is present in Mallory bodies and is elevated in alcoholic cirrhosis and alcoholic hepatitis. K18 expression is modulated by interleukin 6 (IL-6). K18 interacts with desmosomal protein/ E-cadherin and promotes cell adhesion. CK18 is cleaved by caspases during apoptosis and released into blood as caspase cleaved cytokeratin-18 (CCCK18).
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Interleukin-6 Induces keratin expression in intestinal epithelial cells potential role of Keratin-8 in interleukin-6-induced barrier function alterations
Wang L, et al.
The Journal of Biological Chemistry, 282(11), 8219-8227 (2007)
Cytokeratin 18-associated Histone 3 Modulation in Hepatocellular Carcinoma: A Mini Review
Lai YCC, et al.
Cancer, Genomics, and Proteomics, 14(4), 219-223 (2017)
High serum levels of caspase-cleaved cytokeratin-18 are associated with malignant middle cerebral artery infarction patient mortality
Lorente L, et al.
BMC Neurology, 18(1), 32-32 (2018)
TP53 mutation, epithelial-mesenchymal transition, and stem like features in breast cancer subtypes
Coradini D, et al.
BioMed Research International, 2012 (2012)
Cell death and prognosis of mortality in alcoholic hepatitis patients using plasma keratin-18
Woolbright BL, et al.
Gene Expression, 17(4), 301-312 (2017)
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