推荐产品
生物源
mouse
共軛
FITC conjugate
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
MEM-259, monoclonal
形狀
buffered aqueous solution
物種活性
human
技術
flow cytometry: suitable
同型
IgG1
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
2-8°C
目標翻譯後修改
unmodified
基因資訊
human ... CD63(967)
相关类别
一般說明
CD63 belongs to the transmembrane 4 superfamily (TM4SF). CD63 is an integral membrane glycoprotein expressed in late endosomes and lysosomes, and is also present in the platelet dense granule membrane.
免疫原
HPB-ALL T cell line
應用
The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.
生化／生理作用
CD63 is one of the platelet activation marker, which plays a vital role in platelet aggregation, adhesion to collagen, uptake of oxidized low-density lipoprotein (LDL) in vitro and regulation of angiogenesis. Improved metabolic control deduce platelet activation marker in the type-2 diabetes patients and helps in reducing development of diabetic late complications. Inadequate expression of CD63 results in the autosomal recessive inherited disorder, Hermansky-Pudlak syndrome. CD63 is associated with various cellular functions such as cellular adhesion, cell differentiation, migration, carcinogenesis, and tumor progression. CD63 is highly expressed in initial stage of Merkel cell carcinoma and decreased in later stages; therefore, CD63 is considered to be a potential prognostic factor for this malignancy.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin.
Nishibori M, et al.
The Journal of Clinical Investigation, 91(4), 1775-1782 (1993)
Improved metabolic control decreases platelet activation markers in patients with type-2 diabetes.
Eibl N, et al.
European Journal of Clinical Investigation, 34(3), 205-209 (2004)
Expression of the tetraspanins CD9, CD37, CD63, and CD151 in Merkel cell carcinoma: strong evidence for a posttranscriptional fine-tuning of CD9 gene expression.
Woegerbauer M, et al.
Modern Pathology, 23(5), 751-762 (2010)
A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase.
Berditchevski F, et al.
The Journal of Biological Chemistry, 272(5), 2595-2598 (1997)
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