价格与库存信息目前不能提供
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 38 kDa
种属反应性
human
浓度
~1 mg/mL
技术
ELISA: 1:40000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... GP174(84636)
一般描述
G protein-coupled receptor 174 (GPR174) is a 333 amino acid protein encoded by the gene with one exon mapped to human chromosome Xq21.1. GPR174 is a member of G protein–coupled receptor 1(GPCR1) / rhodopsin-like family. The encoded protein consists of seven α -helical transmembrane domains. The protein is predominantly expressed in immune related tissues, and it is expressed at low levels in thyroid.
免疫原
The antiserum was produced against synthesized peptide derived from human GPR174.
Immunogen Range: 131-180
Immunogen Range: 131-180
生化/生理作用
G protein-coupled receptor 174 (GPR174) plays a vital role in inducing signal transduction in immune cells. GPR174 upon lysophosphatidylserine (LysoPS) binding, enhances the production of intracellular cyclic adenosine monophosphate (cAMP) in a dose dependent manner. Mutation in GPR174 gene can be a risk factor for Graves′ disease (GD) and autoimmune addison′s disease (AAD). Upregulation of intracellular cAMP by GPR174 leads to the inhibition of immune cell proliferation. GPR174, as a LysoPS receptor, might play a crucial role in the central nervous system. Alteration in the expression of the gene results in vasovagal syncope (VVS). Overexpression of GPR174 is observed in subcutaneous metastases. Lysophosphatidylserine (LysoPS) secreted by the immune system in vivo, acts as a ligand for GPR174.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
An X chromosome-wide association analysis identifies variants in GPR174 as a risk factor for Graves' disease.
Chu X, et al.
Journal of medical Genetics, 50(7), 479-485 (2013)
Alteration of gene expression profiling including GPR174 and GNG2 is associated with vasovagal syncope.
Huang YJ, et al.
Pediatric Cardiology, 36(3), 475-480 (2015)
Role of the X-linked gene GPR174 in autoimmune Addison's disease.
Napier C, et al.
The Journal of Clinical Endocrinology and Metabolism, 100(1), E187-E190 (2015)
Y Qin et al.
Pigment cell & melanoma research, 24(1), 207-218 (2010-10-01)
G-protein-coupled receptors (GPCRs) have been implicated in the tumorigenesis and metastasis of human cancers and are considered amongst the most desirable targets for drug development. Utilizing a robust quantitative PCR array, we quantified expression of 94 human GPCRs, including 75
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