推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 23 kDa
物種活性
mouse, human, rat
濃度
~1 mg/mL
技術
ELISA: 1:10000
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... TIMP1(7076)
一般說明
The TIMP1 (TIMP metallopeptidase inhibitor 1) gene is mapped to human chromosome Xp11.3.
Tissue inhibitors of metalloproteinase 1 (TIMP1) is a member of TIMPs protein family. It is widely expressed in most of the human tissues and body fluids. TIMP1 is a wedge shaped protein with five β-strands, a central helical region representing the interface of the two domains and a C-terminal β-structure.
免疫原
The antiserum was produced against synthesized peptide derived from human TIMP1.
Immunogen Range: 61-110
Immunogen Range: 61-110
應用
Anti-TIMP1 antibody produced in rabbit has been used in western blotting.
生化/生理作用
TIMP1 (TIMP metallopeptidase inhibitor 1) mediates the communication between tumor cells and cancer associated fibroblasts and contributes to tumor progression in condition such as hepatocellular carcinoma. The encoded protein is a cytokine tissue inhibitor. Timp1 regulates the activity of matrix metalloproteinases (MMP) especially MMP-8 and -9. Imbalance in Timp1 levels lowers the fibrotic material in the extracellular matrix and results in inflammation. This might contribute to the pathogenesis of myocardial fibrosis, atherosclerosis and acute coronary syndrome. Timp1 level serves as an important biomarker in the development of sepsis.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品?
试试我们的产品选型工具.
儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
nwg
閃點(°F)
Not applicable
閃點(°C)
Not applicable
TIMPs as multifacial proteins
Critical Reviews in Oncology/Hematology, 49(3), 187-198 (2004)
IL-6/STAT3 axis initiated CAFs via up-regulating TIMP-1 which was attenuated by acetylation of STAT3 induced by PCAF in HCC microenvironment.
Cellular Signalling, 28(9), 1314-1324 (2016)
Low MMP-8/TIMP-1 reflects left ventricle impairment in takotsubo cardiomyopathy and high TIMP-1 may help to differentiate it from acute coronary syndrome.
PLoS ONE, 12(3), 1-11 (2017)
Genetic polymorphisms and plasma levels of BCL11A contribute to the development of laryngeal squamous cell carcinoma.
PLoS ONE, 12(2), 1-11 (2017)
Genome-wide scan of exfoliation syndrome.
Investigative Ophthalmology & Visual Science, 48(9), 4136-4142 (2007)
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门