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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 164 kDa
物種活性
human
濃度
~1 mg/mL
技術
ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... LMTK2(22853)
一般說明
Anti-LMTK2 antibody detects endogenous levels of total LMTK2 protein.
Lemur tyrosine kinase 2 (LMTK2) is a serine/threonine kinase, located in endosomal compartments. It is also termed as BREK (brain-enriched kinase), AATYK-2 (apoptosis-associated tyrosine kinase 2), cdk5, KPI-2 and Cprk. It is expressed at high levels in the plasma membrane. LMTK2 consists of 1503 amino acids and is located on human chromosome 7q21.
免疫原
The antiserum was produced against synthesized peptide derived from human LMTK2.
Immunogen Range: 651-700
Immunogen Range: 651-700
應用
Anti-LMTK2 antibody has been used in western blotting.
生化／生理作用
Lemur tyrosine kinase 2 (LMTK2) participates in endosomal membrane trafficking and neuronal physiology. It also participates in the differentiation of tissues and acts as a negative regulator of nerve growth factor (NGF)-induced neuronal differentiation.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Lemur tyrosine kinase 2 (LMTK2) is a determinant of cell sensitivity to apoptosis by regulating the levels of the BCL2 family members
Conti A, et al.
Cancer Letters, 389, 59-69 (2017)
Rongjing Zhang et al.
Cancer letters, 454, 70-77 (2019-04-14)
Lemur tyrosine kinase 2 (LMTK2) belongs to both protein kinase and tyrosine kinase families. LMTK2 is less studied and little is known about its function. Here we demonstrate that LMTK2 modulates NF-κB activity and functions to promote colonic tumorigenesis. We
Signal dependent ER export of lemur tyrosine kinase 2
Butler EC and Bradbury NA
BMC Cell Biology, 16(1), 26-26 (2015)
Prostate cancer genomics: can we distinguish between indolent and fatal disease using genetic markers?
Wiklund F
Genome Medicine, 2(7), 45-45 (2010)
Daniel F Cruz et al.
Frontiers in oncology, 11, 596861-596861 (2021-04-06)
Lemur tyrosine kinase 2 (LMTK2) is a transmembrane Ser/Thr kinase whose role has been increasingly recognized; however, when compared to other kinases, understanding of the LMTK2 networks and biological functions is still limited. Recent data have shown that transforming growth
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