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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 23 kDa
物種活性
rat, mouse, human
濃度
~1 mg/mL
技術
ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CLDN3(1365)
一般說明
Anti-Claudin 3 Antibody detects endogenous levels of total Claudin 3 protein.
Claudin-3 (CLDN3) is a tetraspanin transmembrane protein, that is mapped to human chromosome 7q11.23.
免疫原
The antiserum was produced against synthesized peptide derived from human Claudin 3.
Immunogen Range: 171-220
Immunogen Range: 171-220
應用
Anti-Claudin 3, C-Terminal antibody has been used in immunofluorescence and western blotting.
生化／生理作用
In submandibular gland, claudin-3 (CLDN3) controls paracellular permeability with the help of TNF-α(tumor necrosis factor α). High level expression of CLDN3 improves the malignant ability of colorectal cancer cells. It participates in the organization and activities of tight junctions (TJs).
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Claudin-3 overexpression increases the malignant potential of colorectal cancer cells: roles of ERK1/2 and PI3K-Akt as modulators of EGFR signaling
de Souza WF, et al.
PLoS ONE (2013)
Generation of specific monoclonal antibodies against the extracellular loops of human claudin-3 by immunizing mice with target-expressing cells
Ando H, et al.
Bioscience, Biotechnology, and Biochemistry, 79(8), 1272-1279 (2015)
Claudin-3 is required for modulation of paracellular permeability by TNF-? through ERK1/2/slug signaling axis in submandibular gland
Mei M, et al.
Cellular Signalling, 27(10), 1915-1927 (2015)
Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel
Wilmes A, et al.
Toxicology and Applied Pharmacology, 279(2), 163-172 (2014)
Katharina M C Klee et al.
Human genetics, 139(10), 1247-1259 (2020-04-20)
Congenital diarrheal disorders (CDD) comprise > 50 monogenic entities featuring chronic diarrhea of early-onset, including defects in nutrient and electrolyte absorption, enterocyte polarization, enteroendocrine cell differentiation, and epithelial integrity. Diarrhea is also a predominant symptom in many immunodeficiencies, congenital disorders of glycosylation
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