SAB4500043
Anti-G3BP-1 antibody produced in rabbit
affinity isolated antibody
别名:
ATP-dependent DNA helicase VIII, G3BP-1, GAP SH3 domain-binding protein 1, HDH-VIII, Ras GTPase-activating protein-binding protein 1
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100 μG
$635.00
$635.00
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100 μG
$635.00
About This Item
$635.00
请联系客服了解存货情况
新价格，新优惠！
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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 52 kDa
种属反应性
mouse, human
浓度
~1 mg/mL
技术
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... G3BP1(10146)
一般描述
Anti-G3BP-1 Antibody detects endogenous levels of total G3BP-1 protein.
G3BP1 (ras-GTPase-activating protein SH3 domain-binding protein 1) is a constituent of SGs (stress granules). It is located on human chromosome 5q14.2-5q33.3.
免疫原
The antiserum was produced against synthesized peptide derived from human G3BP-1.
Immunogen Range: 199-248
Immunogen Range: 199-248
生化/生理作用
G3BP1 (ras-GTPase-activating protein SH3 domain-binding protein 1) blocks the replication of HIV-1 (human immunodeficiency virus) in macrophages and T-cells. In gastric cancer patients, overexpression of G3BP1 leads to imperfect clinical predictions. It is required for the interactions of SG–PB (stress granule-processing bodies).
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Novel Role of Ras-GTPase Activating Protein SH3 Domain-Binding Protein G3BP in Adhesion and Migration of 32D Myeloid Progenitor Cells
Schwarz K, et al.
The Open Hematology Journal, 6 (2012)
G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA.
Aulas A, et al.
The Journal of Cell Biology, 209(1), 73-84 (2015)
Overexpression of Ras-GTPase-activating protein SH3 domain-binding protein 1 correlates with poor prognosis in gastric cancer patients
Min L, et al.
Histopathology, 67(5), 677-688 (2015)
G3BP1 restricts HIV-1 replication in macrophages and T-cells by sequestering viral RNA
Jimenez VC, et al.
Virology, 486, 94-104 (2015)
Hideaki Matsuki et al.
Genes to cells : devoted to molecular & cellular mechanisms, 18(2), 135-146 (2013-01-03)
Upon exposure to various environmental stresses such as arsenite, hypoxia, and heat shock, cells inhibit their translation and apoptosis and then repair stress-induced alterations, such as DNA damage and the accumulation of misfolded proteins. These types of stresses induce the
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