SAB4300396

Anti-CHUK (Ab-23) antibody produced in rabbit

affinity isolated antibody

• 别名: Anti-IKBKA antibody produced in rabbit, Anti-IKK-alpha antibody produced in rabbit, Anti-IKK1 antibody produced in rabbit, Anti-IKKA antibody produced in rabbit, Anti-conserved helix-loop-helix ubiquitous kinase antibody produced in rabbit
• MDL编号: MFCD02096685
• UNSPSC代码: 12352203
• NACRES: NA.41

属性

• 生物来源: rabbit
• 质量水平: 100
• 偶联物: unconjugated
• 抗体形式: affinity isolated antibody
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 表单: buffered aqueous solution
• 分子量: ~85 kDa
• 种属反应性: rat, human, mouse
• 浓度: 1 mg/mL
• 技术: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000
• 同位素/亚型: IgG
• 免疫原序列: (L-G-T-G-G)
• NCBI登记号: NP_001269.3
• UniProt登记号: O15111
• 运输: wet ice
• 储存温度: −20°C
• 靶向翻译后修饰: unmodified
• 基因信息: human ... CHUK(1147)

说明

免疫原

Peptide sequence around aa. 21-25 (L-G-T-G-G), according to the protein CHUK.

特点和优势

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目标描述

Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable