SAB4200611

Anti-DKC1 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• 别名: Anti-CBF5, Anti-CBF5 homolog, Anti-DKC, Anti-H/ACA ribonucleoprotein complex subunit 4, Anti-NAP57, Anti-NOLA4, Anti-XAP101, Anti-cbf5p homolog, Anti-dyskeratosis congenita 1, Anti-dyskerin, Anti-nopp140-associated protein of 57 kDa, Anti-nucleolar protein family A member 4, Anti-snoRNP protein DKC1
• UNSPSC代码: 12352203
• NACRES: NA.41

属性

• 生物来源: rabbit
• 偶联物: unconjugated
• 抗体形式: affinity isolated antibody
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 表单: buffered aqueous solution
• 分子量: antigen ~57 kDa
• 种属反应性: human, mouse
• 浓度: ~1.0 mg/mL
• 技术: immunoblotting: 0.5-1.0 μg/mL using whole extracts of mouse Hepa1-6 cells or nuclear extract of HeLa cells.
• UniProt登记号: O60832
• 运输: dry ice
• 储存温度: −20°C
• 靶向翻译后修饰: unmodified
• 基因信息: human ... DKC1(1736)

说明

一般描述

Dyskerin is a nucleolar protein encoded by the DKC1 gene. This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. The DKC1 gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein gene and is transcribed in a telomere to centromere direction.

免疫原

peptide corresponding to the N-terminal region of human DKC1, conjugated to KLH. The corresponding sequence is identical in monkey, bovine, pig and dog and differs by a single amino acid in mouse and rat.

应用

Anti-DKC1 antibody has been used in immunoblotting.

生化/生理作用

Dyskerin and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Mutations in the DKC1 gene cause X-linked dyskeratosis congenita, aplastic anemia and progressive bone marrow failure in most cases. It also leads to a disease resulting in reticulate skin pigmentation, mucosal leukoplakia, nail dystrophy. It also causes Hoyeraal-Hreidarsson syndrome, which is a more severe form of dyskeratosis congenita. The overexpression of dyskerin has been observed in many cancers including neuroblastoma, colorectal cancer, lymphoma, breast cancer, melanoma, prostate cancer, ovarian carcinoma and hepatocellular carcinoma.

外形

a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 储存分类代码: 10 - Combustible liquids
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable