生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~86 kDa
种属反应性
mouse, rat, human
浓度
~1.0 mg/mL
技术
immunoprecipitation (IP): 5-10 μg using lysates of human HeLa cells.
indirect immunofluorescence: 1-2 μg/mL using human HeLa cells.
western blot: 2.5-5.0 μg/mL using whole extracts of mouse LA-4 and rat PC12 cells.
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... COG7(91949)
mouse ... Cog7(233824)
rat ... Cog7(293456)
一般描述
Conserved Oligomeric Golgi complex 7 (COG7) protein belongs to the COG complex. COG complex is composed of eight distinct subunits organized in two heterotrimeric groups, COG2, 3, 4 and COG5, 6, 7 which are linked via a dimeric group formed by COG1 and COG8. COG complex is an evolutionarily conserved multi-subunit protein complex. The COG7 gene is located on the human chromosome at 16p12.2.
特异性
Anti-COG7 recognizes human, mouse and rat COG7.
免疫原
peptide corresponding to an internal region of human COG7, conjugated to KLH. The corresponding sequence is identical in mouse and rat COG7.
应用
Anti-COG7 antibody produced in rabbit may be used in:
- immunoblotting
- immunoprecipitation
- immunofluorescence
生化/生理作用
Conserved Oligomeric Golgi complex (COG) modulates membrane trafficking and maintenance of Golgi glycosylation machinery in eukaryotic cells. COG7 protein is involved in retrograde vesicular trafficking. Mutations in the COG7 gene leads to type IIe congenital disorder of glycosylation.
外形
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
储存及稳定性
For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Renate Zeevaert et al.
European journal of medical genetics, 52(5), 303-305 (2009-07-07)
We describe a patient homozygous for a novel mutation in COG7, coding for one of the subunits of the Conserved Oligomeric Golgi complex, involved in retrograde vesicular trafficking. His brother showed a similar clinical syndrome and glycosylation defect but no
Eva Morava et al.
European journal of human genetics : EJHG, 15(6), 638-645 (2007-03-16)
We describe the clinical and biochemical characteristics in three patients from two different families diagnosed with Congenital Disorder of Glycosylation type IIe owing to a defect in Conserved Oligomeric Golgi complex (COG)7; one of the eight subunits of the COG.
G Charles Ostermeier et al.
Journal of andrology, 26(1), 70-74 (2004-12-22)
We recently described a complex population of spermatozoal coding RNAs that are delivered to the oocyte on fertilization. These are derived throughout spermatogenesis, representing a record of past events. Recently, evidence has been provided that micro-RNAs are present in testes
Rita Quental et al.
BMC evolutionary biology, 10, 212-212 (2010-07-17)
The Conserved Oligomeric Golgi (COG) complex is an eight-subunit assembly that localizes peripherally to Golgi membranes and is involved in retrograde vesicular trafficking. COG subunits are organized in two heterotrimeric groups, Cog2, -3, -4 and Cog5, -6, -7, linked by
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