SAB4200434

Anti-VHL antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• 别名: Anti-HRCA1, Anti-RCA1, Anti-VHL1, Anti-Von Hippel-Lindau tumor supressor
• UNSPSC代码: 12352203
• NACRES: NA.41

属性

• 生物来源: rabbit
• 偶联物: unconjugated
• 抗体形式: affinity isolated antibody
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 表单: buffered aqueous solution
• 分子量: antigen ~30 kDa
• 种属反应性: human
• 浓度: ~1.0 mg/mL
• 技术: immunoprecipitation (IP): 5-10 μg using lysates of HEK-293T cells overexpressing human VHL; indirect immunofluorescence: 5-10 μg/mL using HeLa cells; western blot: 1.5-3.0 μg/mL using lysates of HEK-293T cells overexpressing human VHL
• UniProt登记号: P40337
• 运输: dry ice
• 储存温度: −20°C
• 靶向翻译后修饰: unmodified
• 基因信息: human ... VHL(7428)

说明

一般描述

Von Hippel-Lindau tumor suppressor (VHL) is encoded by the gene mapped to human chromosome 3p25. The encoded protein is mainly expressed in adult brain and kidney. It is specifically localized on the cell membrane.

免疫原

synthetic peptide corresponding to a sequence near the C-terminus of human VHL, conjugated to KLH. The corresponding sequence is identical in human VHL isoform 2 and highly conserved (94% sequence identity) in rat VHL.

应用

Anti-VHL antibody produced in rabbit has been used in immunoblotting, immunoprecipitation and immunofluorescence.

生化/生理作用

VHL acts as part of an E3 ubiquitin ligase that targets hypoxia-inducible factor α (HIF α) for rapid proteasomal degradation under normoxic conditions. VHL has been also identified as a key regulator of microtubule dynamic stability.

Von Hippel-Lindau tumor suppressor (VHL) acts as a tumor suppressor in some cancers. It might also play a vital role in signal transduction or cell adhesion. Mutation in the gene is associated with the development of sporadic cerebellar hemangioblastoma tumorigenesis and von Hippel-Lindau (VHL) disease. Interaction of the protein with hypoxia-inducible factor-1 (HIF-1) induces mammalian oxygen sensing.

外形

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 储存分类代码: 10 - Combustible liquids
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable