SAB4200398
Anti-TFRC antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-CD71, Anti-TFR, Anti-TFR1, Anti-TR, Anti-TRFR, Anti-Transferrin receptor (p90, CD71), Anti-Transferrin receptor protein 1, Anti-p90, AntiT9
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200 μL
$768.00
About This Item
UNSPSC代码:
12352203
NACRES:
NA.41
推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~90 kDa
种属反应性
mouse, rat, human
浓度
~1.0 mg/mL
技术
indirect immunofluorescence: 10-20 μg/mL using rat NRK cells
western blot: 2.5-5.0 μg/mL using whole extracts of human U-2-OS and mouse Neuro-2a cells
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TFRC(7037)
mouse ... Tfrc(22042)
rat ... Tfrc(64678)
一般描述
Transferrin receptor (TFRC), also known as p90, CD71, TFR and TFR1, is a transmembrane glycoprotein. It is composed of two disulphide-bonded sub-units, contains three N-linked glycan units and is post-translationally modified with phosphate and fatty acyl groups.
免疫原
synthetic peptide corresponding to an internal sequence of human TFRC, conjugated to KLH
应用
Anti-TFRC antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
生化/生理作用
Transferrin receptor (TFRC) mediates cellular iron uptake. It binds iron bound transferrin on the cell surface, and the receptor ligand complex undergoes endocytosis via clathrin coated pits. Endosomal acidification leads to iron release, which is transported to the cytosol or to the mitochondria in erythroid cells. The apotransferrin receptor complex is then recycled to the cell surface, where the affinity of apotransferrin for TFRC drops, resulting in its dissociation. TFRC is necessary for development of erythrocytes and the nervous system.
外形
solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
1.6 Mb deletion in chromosome band 3q29 associated with eye abnormalities
Tyshchenko N, et al.
European Journal of Medical Genetics, 52(2-3), 128-130 (2009)
Patrizia Sarogni et al.
Advanced biology, 7(10), e2200229-e2200229 (2023-03-03)
Pancreatic cancer has a poor prognosis due to its aggressive nature and ability to metastasize at an early stage. Currently, its management is still a challenge because this neoplasm is resistant to conventional treatment approaches, among which is chemo-radiotherapy (CRT), due
Transferrin receptor gene and protein expression and localization in human IUGR and normal term placentas
Mando C, et al.
Placenta, 32(1), 44-50 (2011)
Peina Wang et al.
Antioxidants (Basel, Switzerland), 11(7) (2022-07-28)
Blood-brain barrier (BBB) breakdown, a characteristic feature of ischemic stroke, contributes to poor patient outcomes. Brain microvascular endothelial cells (BMVECs) are a key component of the BBB and dysfunction or death of these cells following cerebral ischemia reperfusion (I/R) injury
Yidan Liang et al.
Brain research bulletin, 207, 110878-110878 (2024-01-14)
Cerebrovascular dysfunction resulting from traumatic brain injury (TBI) significantly contributes to poor patient outcomes. Recent studies revealed the involvement of iron metabolism in neuronal survival, yet its effect on vasculature remains unclear. This study aims to explore the impact of
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