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生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~195 kDa
种属反应性
mouse, human
浓度
~1.0 mg/mL
技术
indirect immunofluorescence: 2-5 μg/mL using paraformaldehyde fixed NIH-3T3 cells
western blot: 2-4 μg/mL using nuclear extract of HEK-293T
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... XRN1(54464)
mouse ... Xrn1(24127)
rat ... Xrn1(300944)
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一般描述
5→3′ exoribonuclease 1 (XRN1) is a cytoplasmic enzyme, encoded by the gene mapped to human chromosome 3q23. The encoded protein has a molecular mass of 175kDa and is a member of XRN family of exoribonucleases. It is mainly localized in cytoplasmic P- bodies.
应用
Anti-XRN1 antibody produced in rabbit has been used in:
- immunostaining
- immunoblotting
- immunofluorescence.
生化/生理作用
5→3′ exoribonuclease 1 (XRN1) catalyzes the degradation of decapped (5′ monophosphorylated) RNA in the 5′→3′ direction. In addition, it also degrades tRNA (iMet) that is distributed in the cytoplasm. XRN1 is implicated in the modulation of dsRNA accumulation and dsRNA-responsive innate immune effectors. The encoded protein also plays an essential role in maintaining the fidelity of cellular RNA turnover in eukaryotes. XRN1 is required for proper bone formation in humans. Therefore, mutation in the gene leads to development of osteosarcoma.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Alternative RISC assembly: Binding and repression of microRNA-mRNA duplexes by human Ago proteins
Janas MM, et al.
RNA, 18(11), 2041-2055 (2012)
Degradation of initiator tRNAMet by Xrn1/2 via its accumulation in the nucleus of heat-treated HeLa cells.
Watanabe K
Nucleic Acids Research, 41, 4671-4685 (2013)
Comparison between osteoblasts derived from human dental pulp stem cells and osteosarcoma cell lines.
Palmieri A
Cell Biology International, 32, 733-733 (2008)
XRN 5'?3' exoribonucleases: structure, mechanisms and functions.
Nagarajan VK
Biochimica et Biophysica Acta, 1829, 590-603 (2013)
Maja M Janas et al.
RNA (New York, N.Y.), 18(11), 2041-2055 (2012-09-29)
MicroRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally regulate protein output from the majority of human mRNAs. In contrast to the consensus view that all miRNAs are associated with Argonaute (Ago) proteins, we determine that miRNAs are expressed in a
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