SAB4100064
Monoclonal Anti-IDH1 antibody produced in mouse
clone IDH1-A36, culture supernatant
别名:
Anti-IDH, Anti-IDP, Anti-IDPC, Anti-Isocitrate dehydrogenase 1 (NADP+), soluble (IDH1), Anti-NADP+-specific ICDH, Anti-NADP-dependent isocitrate dehydrogenase, cytosolic, Anti-NADP-dependent isocitrate dehydrogenase, peroxisomal, Anti-Oxalosuccinate decarboxylase, Anti-PICD
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所有图片(3)
About This Item
UNSPSC代码:
12352203
NACRES:
NA.41
生物来源
mouse
偶联物
unconjugated
抗体形式
culture supernatant
抗体产品类型
primary antibodies
克隆
IDH1-A36, monoclonal
表单
aqueous solution
分子量
antigen predicted mol wt 46.7 kDa
种属反应性
human
技术
western blot: suitable
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... IDH1(3417)
一般描述
Isocitrate dehydrogenase 1 (IDH1) is encoded by the gene mapped to human chromosome 2q34. It is a member of the isocitrate dehydrogenase enzymes family. IDH1 is mainly found in cytoplasm and peroxisomes.
免疫原
IDH1 purified recombinant protein
生化/生理作用
Isocitrate dehydrogenase 1 (IDH1) acts as a regulator of cytoplasmic and peroxisomal lipid metabolism in various tissues. It catalyzes the conversion of isocitrate to α-ketoglutarate, which is a key cofactor for 2-OG-dependent dioxygenases. IDH1 facilitates various cellular processes such as adaptation to hypoxia, histone demethylation and DNA modification. It is also involved in the synthesis of plasmalogen lipids in peroxisomes. Somatic mutation of the gene is associated with the development of gliomas and acute myeloid leukaemia (AML).
外形
Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
IDH1, lipid metabolism and cancer: Shedding new light on old ideas
Bogdanovic E
Biochim. Biophys. Acta Gen. Subj., 1850(9), 1781-1785 (2015)
IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours
Amary MF, et al.
The Journal of Pathology, 224(3), 334-343 (2011)
IDH1/2 mutation detection in gliomas
Arita H, et al.
Brain Tumor Pathology, 32(2), 79-89 (2015)
M Udugama et al.
Nature communications, 12(1), 2584-2584 (2021-05-12)
Alternative Lengthening of Telomeres (ALT) is a telomere maintenance pathway utilised in 15% of cancers. ALT cancers are strongly associated with inactivating mutations in ATRX; yet loss of ATRX alone is insufficient to trigger ALT, suggesting that additional cooperating factors
Julie-Aurore Losman et al.
Science (New York, N.Y.), 339(6127), 1621-1625 (2013-02-09)
Mutations in IDH1 and IDH2, the genes coding for isocitrate dehydrogenases 1 and 2, are common in several human cancers, including leukemias, and result in overproduction of the (R)-enantiomer of 2-hydroxyglutarate [(R)-2HG]. Elucidation of the role of IDH mutations and
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