SAB3701388

Anti-Human IgG IgA IgM (H+L), F(ab′)₂ fragment, highly cross adsorbed-Biotin antibody produced in goat

affinity isolated antibody, lyophilized powder

• UNSPSC代码: 12352203
• NACRES: NA.46

属性

• 生物来源: goat
• 偶联物: biotin conjugate
• 抗体形式: affinity isolated antibody
• 抗体产品类型: secondary antibodies
• 克隆: polyclonal
• 表单: lyophilized powder
• 种属反应性: human
• 技术: immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• 运输: wet ice
• 储存温度: 2-8°C
• 靶向翻译后修饰: unmodified

说明

一般描述

Immunoglobulin G (IgG) belongs to the immunoglobulin family and is a widely expressed serum antibody. It consists of a gamma (γ) heavy chain in the constant (C) region. The monomeric 150 kDa structure of IgG constitutes two identical heavy chains and two identical light chains with molecular weight of 50 kDa and 25 kDa, respectively. The primary structure of this antibody also contains disulfide bonds involved in linking the two heavy chains, linking the heavy and light chains and resides inside the chains. IgG is further subdivided into four classes namely, IgG1, IgG2, IgG3, and IgG4 with different heavy chains, named γ1, γ2, γ3, and γ4, respectively. Immunoglobulin M (IgM) exists as a pentamer in the serum and has a high molecular weight. Monomeric IgM has a molecular weight of 190 kDa. The pentameric IgM consists of ten μ-heavy chains, ten light chains and a single J-chain which is linked by disulphide bonds. The μ-chain consists of five domains- VH, Cμ1, Cμ2, Cμ3 and Cμ4. Immunoglobulin A (IgA) is found as two subclasses, that is, IgA1 and IgA2. IgA1 has an extended hinge because of the insertion of a duplicated stretch of amino acids, whereas IgA2 lacks this. IgA exists as a monomer or dimer in the secreted form. Dimeric IgA has a molecular weight of 390 kDa. This antibody can form multimers and its polymerization is essential for transport across epithelia. IgA is crucial as the first line of defence.

特异性

This product was prepared from polyspecific antiserum by immunoaffinity chromatography using antigens coupled to agarose beads followed by solid phase adsorption(s) to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against Anti-Biotin and Anti-Goat Serum. No reaction was observed against Mouse Serum proteins. This product is suitable for the detection of all Human immuno-globulin classes, isotypes and chain combinations.

免疫原

Human IgG, IgA and IgM whole molecules

物理属性

Antibody format: IgG F(ab′)2

外形

Supplied in 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 10 mg/mL Bovine Serum Albumin (BSA) - Immunoglobulin and Protease free

重悬

Reconstitute with 1.0 mL deionized water (or equivalent).

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 象形图: GHS06,GHS09
• 警示用语：: Danger
• 危险声明: H302,H311,H411
• 预防措施声明: P280 - P301 + P312 + P330 - P302 + P352 + P312
• 危险分类: Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 2
• 补充剂危害: EUH032
• 储存分类代码: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable