Bonzo Antibody: Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, and CCR2b in the chemokine receptor family have been identified as HIV coreceptors. An orphan G protein-coupled receptor was recently cloned and designated Bonzo, STRL33 and TYMSTR, and identified as HIV and SIV coreceptor. Bonzo/STRL33 is used by SIV, HIV-2 and HIV-1. The messenger RNA of Bonzo/STRL33 is expressed in lymphoid tissues and activated peripheral blood lymphocytes.
免疫原
Bonzo antibody was raised against a 20 amino acid peptide near the carboxy terminus of human Bonzo.The immunogen is located within the last 50 amino acids of Bonzo.
应用
Bonzo antibody can be used for detection of Bonzo by Western blot at 1:1000 dilution. Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
