This antibody detects the N-terminal domain of Gasdermin A. The identities of the extra bands have not been determined, and it is unlikely that this antibody would cross-react with the C-terminal domain. Higher molecular weight bands could potentially correspond to an aggregate, but this has not been evaluated.
$604.00
预计发货时间2025年8月18日详情
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生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
49365 Da
种属反应性
mouse, human
技术
flow cytometry: 1:10-1:50
immunohistochemistry: 1:50-1:100
western blot: 1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... GSDMA(284110)
一般描述
Gasdermin A (GSDMA) is located at 17q21.1 on the human chromosome. Its molecular weight is 49 kDa. GSDMA is localized in the pit cells of the gastric epithelium.
生化/生理作用
Gasdermin A (GSDMA) plays a major role in regulating the tumor growth factor- β (TGF-β) and induces apoptosis. Mutation in this gene leads to gastric adenocarcinoma.
外形
Supplied in PBS with 0.09% (W/V) sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
GSDMA (gasdermin A)
Saeki N and Sasaki H
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2011)
Caspase-11-Mediated Hepatocytic Pyroptosis Promotes the Progression of Nonalcoholic Steatohepatitis.
Yingwei Zhu et al.
Cellular and molecular gastroenterology and hepatology, 12(2), 653-664 (2021-04-25)
Nonalcoholic steatohepatitis (NASH) is an inflammatory disease with severe outcomes. Hepatocyte death, including apoptosis, necrosis, and pyroptosis, has been implicated in pathophysiology of NASH. Pyroptosis is mediated by inflammasome activation pathways including caspase-1-mediated canonical signaling pathway and caspase-11-mediated noncanonical signaling
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Are the other bands in the representative blot distinguishing N-terminal domain (~36kDa), C-terminal domain (~28kDa), and a possible oligomer (~95kDa)?
1 answer-
Helpful?
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Hello, what is the Immunogen range of this antibody?
1 answer-
This GSDMA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human GSDMA.
According to the target sequence description and sequence provided on Uniprot, the sequence should be :
PGSSPSDPTDTGNFGFKNMLDTRVEGDVDHelpful?
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