价格与库存信息目前不能提供
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产品名称
ANTI-LC3 (APG8B) (N-TERM) antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
生物源
rabbit
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
14688 Da
物種活性
human, rat
技術
immunofluorescence: 1:100
immunohistochemistry: 1:50-1:100
western blot: 1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... MAP1LC3B(81631)
一般說明
The gene LC3B or MAP1LC3B (microtubule associated protein 1 light chain 3 beta) is a homolog of the ATG8 gene, an autophagy-related gene in yeast. The encoded protein is called pro-MAP1LC3B, a pro-form that is cleaved by ATG4 to produce a cytosolic form called MAP1LC3B-I.
生化／生理作用
MAP1LC3B-I (microtubule associated protein 1 light chain 3 beta-I) conjugates with MAP1LC3B-II before being inserted into both inner and outer membranes of the growing autophagic vesicle during autophagy. The cellular distribution and processing of MAP1LC3B facilitates monitoring of autophagy. Cells that lack MAP1LC3B are found to be defective in the formation of autophagic vesicles, with altered phenotypes associated with the role of autophagy in energy homeostasis and removal of protein aggregates. It can serve as an autophagic marker.
外觀
Supplied in PBS with 0.09% (W/V) sodium azide
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
历史批次信息供参考:
其他客户在看
Autophagic marker MAP1LC3B expression levels are associated with carotid atherosclerosis symptomatology.
Swaminathan B, et al.
PLoS ONE (2014)
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.
Rouschop KM, et al.
The Journal of Clinical Investigation, 120(1), 127-141 (2010)
Anna Churilova et al.
International journal of molecular sciences, 23(14) (2022-07-28)
Autophagy is a regulated mechanism of degradation of misfolded proteins and organelles in the cell. Neurons are highly differentiated cells with extended projections, and therefore, their functioning largely depends on the mechanisms of autophagy. For the first time in an
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