SAB1300869

Anti-THPO (C-term) antibody produced in rabbit

saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution

• 别名: Anti-C-mpl ligand, Anti-ML, Anti-Megakaryocyte colony-stimulating factor, Anti-Thrombopoietin, Myeloproliferative leukemia virus oncogene ligand
• UNSPSC代码: 12352203
• NACRES: NA.41

属性

• 生物来源: rabbit
• 偶联物: unconjugated
• 抗体形式: saturated ammonium sulfate (SAS) precipitated
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 表单: buffered aqueous solution
• 种属反应性: human
• 技术: indirect ELISA: 1:1000; western blot: 1:100-1:500
• NCBI登记号: NP_000451
• UniProt登记号: P40225
• 运输: dry ice
• 储存温度: −20°C
• 靶向翻译后修饰: unmodified
• 基因信息: human ... THPO(7066)

说明

一般描述

Megakaryocytopoiesis is the cellular development process that leads to platelet production. THPO is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. It is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. It is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle.[1] It is an acidic glycoprotein. The gene encoding it is localized on human chromosome 3q27.1.

免疫原

THPO (NP_000451, 305-339)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide at the C-term of human THPO.

生化/生理作用

Thrombopoietin (TPO) stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the cellular proto-oncogene (c-mpl) receptor and acts as an important regulator of circulating platelets. High levels of TPO have been observed in patients with aplastic anemia. Human and murine TPO exhibits cross-species reactivity.

外形

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: nwg
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable