SUMO2 is a ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. SUMO2 does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. This protein plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS isoforms 1-4.
免疫原
SUMO2 (NP_001080085, 1-30) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of Xenopus SUMO2.
外形
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
