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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~100 kDa
物種活性
human, mouse, rat
濃度
~1.0 mg/mL
技術
western blot: 0.1-0.2 μg/mL using whole extract of mouse brain
western blot: 0.5-1.0 μg/mL using rat brain
western blot: 0.5-1.0 μg/mL using whole extracts of human U87 cells
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... STIM2(57620)
mouse ... Stim2(116873)
rat ... Stim2(117087)
一般說明
STIM (stromal interaction molecule) proteins are conserved single-pass transmembrane protein. The three STIM proteins, STIM1, STIM2 and D-Stim, are ubiquitously expressed proteins composed of a single SAM (sterile α-motif) domain and an unpaired EF hand within the highly conserved extracellular region and coiled-coil domains that are conserved in structure and position within the cytoplasmic region. Significant divergence between these proteins was found only at the extreme C-termini. STIM proteins are modified by phosphorylation and N-linked glycosylation.
免疫原
synthetic peptide corresponding to amino acids 812-833 of human STIM2, conjugated to KLH. The corresponding sequence is identical in rat and mouse.
應用
Anti-STIM2 antibody produced in rabbit has been used in western blotting.
生化／生理作用
STIM (stromal interaction molecule) required for the regulation of store-operated Ca2+ influx. Store-operated calcium entry is mediated by Ca2+ release-activated Ca2+ (CRAC) channels, following Ca2+ depletion from the endoplasmic reticulum (ER) stores. This process is crucial for gene transcription, proliferation and cytokine release. STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ entry. STIM2 co-localizes with STIM1 in punctae upon store depletion, and coprecipitates with STIM1 from cell lysates, suggesting that they may play a coordinated role in controlling Ca2+ entry.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Daniel F Gilbert et al.
Frontiers in molecular neuroscience, 9, 111-111 (2016-11-15)
Microglia activation is a neuroinflammatory response to parenchymal damage with release of intracellular metabolites, e.g., purines, and signaling molecules from damaged cells. Extracellular purines can elicit Ca2+-mediated microglia activation involving P2X/P2Y receptors with metabotropic (P2Y) and ionotropic (P2X) cell signaling
STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ Entry
Soboloff J, et al.
Current Biology, 16(14), 1465-1470 (2006)
CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry
Vig M, et al.
Science (New York, N.Y.), 312(5777), 1220-1223 (2006)
A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels
Saul S, et al.
Science Signaling, 9(418), ra26-ra26 (2016)
Store-operated Ca2+ entry (SOCE) and purinergic receptor-mediated Ca2+ homeostasis in murine bv2 microglia cells: early cellular responses to ATP-mediated microglia activation
Gilbert DF, et al.
Frontiers in Molecular Neuroscience, 9, 111-111 (2016)
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