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一般說明
淀粉样蛋白-β(Aβ)肽是阿尔茨海默病大脑的老年斑特征的主要成分。它是一种I型跨膜蛋白。编码淀粉样蛋白-β的基因定位于人21号染色体上。
應用
本品人淀粉样前体蛋白β已用作肽标准品。
生化／生理作用
分泌型β淀粉样蛋白前体(sAPPβ)是β淀粉样蛋白前体(APP)水解得到的裂解产物。APP被β-分泌酶切成2个片段，sAPPβ和β-淀粉样肽(Aβ)。Aβ是阿尔茨海默病(AD)的主要标志之一——淀粉样老年斑的成分，sAPPβ被认为可调节神经元功能和细胞存活。瑞典家系AD中存在的APP突变使APP更易被β-分泌酶切割，形成更多的Aβ和sAPPβ。相反，蛋白激酶C(PKC)激活可降低sAPPβ浓度。反面高尔基体网状结构(TGN)是β-分泌酶活性发挥的主要位点。
外觀
0.2 μm过滤溶液，含20 mM Tris(pH 7.4)、0.5 M NaCl、1 mM EDTA、5 mM βME、2 μg/ml抑肽酶
準備報告
sAPPβ在大肠杆菌中表达为可溶性蛋白，并在非变性条件下纯化。
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
D J Selkoe
Nature, 399(6738 Suppl), A23-A31 (1999-07-07)
Studies of the molecular basis of Alzheimer's disease exemplify the increasingly blurred distinction between basic and applied biomedical research. The four genes so far implicated in familial Alzheimer's disease have each been shown to elevate brain levels of the self-aggregating
Regulation of global gene expression and cell proliferation by APP.
Wu Y
Scientific Reports (2016)
Conformational Dynamics of Specific A? Oligomers Govern Their Ability To Replicate and Induce Neuronal Apoptosis.
Dean DN
Biochemistry (2016)
In vivo BACE1 inhibition leads to brain A? lowering and increased a-secretase processing of APP without effect on Neuregulin-1
Sethu Sankaranarayanan
Journal of Pharmacology and Experimental Therapeutics (2018)
D M Skovronsky et al.
The Journal of biological chemistry, 275(4), 2568-2575 (2000-01-25)
The release of amyloidogenic amyloid-beta peptide (Abeta) from amyloid-beta precursor protein (APP) requires cleavage by beta- and gamma-secretases. In contrast, alpha-secretase cleaves APP within the Abeta sequence and precludes amyloidogenesis. Regulated and unregulated alpha-secretase activities have been reported, and the
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