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Merck
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S4152

Sigma-Aldrich

[D-Arg1, D-Pro2, D-Trp7,9, Leu11]-Substance P acetate salt

≥97% (HPLC)

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About This Item

经验公式（希尔记法）:
C75H108N20O13 · xC2H4O2
CAS号:
143077-65-0
分子量:
1497.79 (free base basis)
MDL编号:
MFCD00133837
UNSPSC代码:
12352202
PubChem化学物质编号:
329824540
NACRES:
NA.26

产品名称

[D-Arg1, D-Pro2, D-Trp7,9, Leu11]-Substance P acetate salt, ≥97% (HPLC)

方案

≥97% (HPLC)

储存温度

−20°C

SMILES字符串

CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]6CCCN6C(=O)[C@H](CCCCN)NC(=O)[C@H]7CCCN7C(=O)[C@H](N)CCCNC(N)=N)C(N)=O

InChI

1S/C75H108N20O13.C2H4O2/c1-42(2)35-55(64(80)98)89-67(101)56(36-43(3)4)90-69(103)59(39-46-41-85-51-23-11-9-20-48(46)51)93-68(102)57(37-44-17-6-5-7-18-44)91-70(104)58(38-45-40-84-50-22-10-8-19-47(45)50)92-66(100)52(27-29-62(78)96)86-65(99)53(28-30-63(79)97)87-71(105)61-26-16-34-95(61)74(108)54(24-12-13-31-76)88-72(106)60-25-15-33-94(60)73(107)49(77)21-14-32-83-75(81)82;1-2(3)4/h5-11,17-20,22-23,40-43,49,52-61,84-85H,12-16,21,24-39,76-77H2,1-4H3,(H2,78,96)(H2,79,97)(H2,80,98)(H,86,99)(H,87,105)(H,88,106)(H,89,101)(H,90,103)(H,91,104)(H,92,100)(H,93,102)(H4,81,82,83);1H3,(H,3,4)/t49-,52+,53+,54+,55+,56+,57+,58-,59-,60-,61+;/m1./s1

InChI key

RXTRFXUUDKVCOG-FDUGBFHGSA-N

Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Trp-Phe-Trp-Leu-Leu-NH2

生化/生理作用

P 物质拮抗剂

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
042H5805
042H58051

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J W Brock et al.
Regulatory peptides, 43(1-2), 65-71 (1993-01-22)
Substance P, which is present in small nerve terminals and proximal to microvessels in rat strated muscle, may have a vasodilator role if released into the microcirculation. Male, Sprague-Dawley rats were anesthetized with sodium pentobarbital (50 mg/kg, i.p.) and the
J W Brock et al.
Microvascular research, 41(1), 24-28 (1991-01-01)
The effects of substance P (SP) on microvessels in the cremaster of sodium pentobarbital-anesthetized male, Sprague-Dawley rats were investigated using closed-circuit television microscopy. Topically added SP (bath concentrations of 10(-13) to 10(-8) M) caused significant dilation of small arterioles. SP
Hyun-Sook Hong et al.
Archives of pharmacal research, 34(12), 2003-2006 (2012-01-03)
Bone marrow is a reservoir for hematopoietic stem cells, endothelial precursor cells, and bone marrow stromal cells (also generally called mesenchymal stem cells), whose positive role in tissue repair is highly anticipated. In this report, we introduce a novel function
T W Moody et al.
Peptides, 16(6), 1133-1140 (1995-01-01)
The effects of neuromedin B (NMB) on C6 glioma cells were investigated. NMB bound with high affinity (IC50 = 1 nM) to C6 cells whereas BN and GRP were less potent (IC50 = 40 and 100 nM). NMB (1 nM)
Jensen, R.T., et al.
Nature, 209, 61-61 (1984)

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