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Merck
所有图片(1)

文件

S166

Sigma-Aldrich

Saclofen

solid

别名:

β-（氨甲基）-4-氯苯乙磺酸

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About This Item

经验公式（希尔记法）:
C9H12ClNO3S
CAS号:
125464-42-8
分子量:
249.71
MDL號碼:
MFCD00216817
分類程式碼代碼:
51111800
PubChem物質ID:
329824485
NACRES:
NA.32

形狀

solid

顏色

white

溶解度

0.1 M NaOH: 20 mg/mL

SMILES 字串

NCC(CS(O)(=O)=O)c1ccc(Cl)cc1

InChI

1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)

InChI 密鑰

JYLNVJYYQQXNEK-UHFFFAOYSA-N

基因資訊

human ... GABBR1(2550) , GABBR2(9568)
mouse ... GABBR1(54393) , GABBR2(242425)
rat ... GABBR1(81657) , GABBR2(83633)

應用

Saclofen已被用于阻止催产素对辣椒素诱导的谷氨酸自发兴奋性传递的抑制作用。
使用Saclofen作为GABAB受体拮抗剂以研究大鼠反复注射羟考酮的镇痛作用。

生化／生理作用

Saclofen可能具有交感神经系统依赖性抗炎作用。
Saclofen是巴氯芬的磺酸类似物，是一种选择性GABAB受体拮抗剂。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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