推荐产品
产品名称
(±)-索他洛尔 盐酸盐, ≥98% (TLC), powder
品質等級
化驗
≥98% (TLC)
形狀
powder
顏色
white to off-white
溶解度
H2O: 20 mg/mL
起源
Bayer
SMILES 字串
Cl.CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1
InChI
1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H
InChI 密鑰
VIDRYROWYFWGSY-UHFFFAOYSA-N
基因資訊
human ... ADRB1(153) , ADRB2(154) , ADRB3(155) , KCNH2(3757)
正在寻找类似产品? 访问 产品对比指南
應用
(±)-Sotalol hydrochloride has been used to test its effect on the cardiac action potential (AP) in human hearts. It has also been used as an β- blocker to determine its effect on free intracellular calcium (Ca2+) release and whole-cell currents in mammalian cancer cells.
生化／生理作用
Potent β-adrenoceptor antagonist; class III antiarrhythmic; prolongs the action potential and increases the refractory period.
Sotalol has a potential to block non-cardioselective β-adrenergic receptors. It acts as an anti-arrhythmic agent and is used as a therapeutic for equine arrhythmias. In addition, sotalol also has an ability to stop atrial fibrillation recurrence.
特點和優勢
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Alexander Burashnikov et al.
Circulation. Arrhythmia and electrophysiology, 5(2), 400-408 (2012-02-11)
Several clinical trials have shown that vernakalant is effective in terminating recent onset atrial fibrillation (AF). The electrophysiological actions of vernakalant are not fully understood. Here we report the results of a blinded study comparing the in vitro canine atrial
Kyle A Arsenault et al.
The Cochrane database of systematic reviews, 1(1), CD003611-CD003611 (2013-02-27)
Atrial fibrillation is a common post-operative complication of cardiac surgery and is associated with an increased risk of post-operative stroke, increased length of intensive care unit and hospital stays, healthcare costs and mortality. Numerous trials have evaluated various pharmacological and
László Drimba et al.
Journal of cardiovascular pharmacology, 60(2), 208-218 (2012-05-25)
High-fat diet and consequent metabolic syndrome (MS) can lead to elevated risk for cardiac arrhythmias. This preclinical study was to investigate if cicletanine (CIC) could produce cardioprotective effects in conscious rabbits exhibiting the main symptoms of MS. NZW rabbits that
[QTc-prolongation in acute drug-poisoning. Guidelines for management from the Swedish Poisons Information Centre].
Jonas Höjer
Lakartidningen, 110(19-20), 953-955 (2013-06-12)
A Antony Muthu Prabhu et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 96, 95-107 (2012-06-05)
The inclusion complexation behavior of salbutamol, sotalol and atenolol drugs with β-cyclodextrin (β-CD) were investigated by UV-visible, fluorometry, time resolved fluorescence, FT-IR, (1)H NMR, SEM and PM3 methods. The above drugs gave a single emission maximum in water where as
商品
DISCOVER Bioactive Small Molecules for Neuroscience
Chromatograms
application for HPLCapplication for HPLCapplication for HPLC我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门