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种属反应性
human
技术
ELISA: suitable
输入
sample type plasma
sample type cell culture supernatant(s)
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
运输
wet ice
储存温度
−20°C
基因信息
human ... CHL1(10752)
一般描述
CHL1 (cell adhesion molecule L1 like) gene codes for a cell-adhesion molecule.[1] It belongs to the L1 family of cell adhesion molecules. The CHL1gene is mapped to human chromosome 3p26.[2]
This ELISA antibody pair detects Human Cell Adhesion Molecule with Homology to L1CAM (L1CAM-2)
应用
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
生化/生理作用
The axon guidance protein encoded by CHL1 (cell adhesion molecule L1 like) gene plays a major role in the guidance of thalamocortical axons and the multiplication and differentiation of neural progenitor cells.[3] CHL1 acts as a tumor-suppressor gene in breast cancer (BC).[1] Mutation in the axon guidance protein results in horizontal gaze palsy with progressive scoliosis (HGPPS).[3] It participates in mental development.[2]
其他说明
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Met. Corr. 1
储存分类代码
8A - Combustible corrosive hazardous materials
闪点(°F)
Not applicable
闪点(°C)
Not applicable
CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancer
Martin-Sanchez E, et al.
Oncotarget, 8(9), 15789-15789 (2017)
Microarray based analysis of an inherited terminal 3p26.3 deletion, containing only the CHL1 gene, from a normal father to his two affected children
Cuoco C et al.
Orphanet Journal of Rare Diseases, 6(1), 12-12 (2011)
Lack of association between the CHL1 gene and adolescent idiopathic scoliosis susceptibility in Han Chinese: a case-control study
Qiu XS, et al.
BMC Musculoskelet. Disord., 15(1), 38-38 (2014)
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