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Merck
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文件

R140

Sigma-Aldrich

Ro 04-6790 二盐酸盐

solid

别名:

4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide dihydrobromide

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About This Item

经验公式（希尔记法）:
C12H16N6O2S · 2HCl
CAS号:
202466-68-0
分子量:
381.28
MDL號碼:
MFCD11045584
分類程式碼代碼:
12352202
PubChem物質ID:
24278570
NACRES:
NA.77

形狀

solid

顏色

white

溶解度

DMSO: >10 mg/mL
H2O: >10 mg/mL

起源

Roche

SMILES 字串

Cl.Cl.CNc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(NC)n1

InChI

1S/C12H16N6O2S.2ClH/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9;;/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18);2*1H

InChI 密鑰

QOAXXMSJHQHSFV-UHFFFAOYSA-N

基因資訊

human ... HTR6(3362)

生化／生理作用

Selective 5-HT6 serotonin receptor antagonist.

特點和優勢

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

注意

Photosensitive

法律資訊

Manufactured and sold under license from Hoffman LaRoche.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

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J C Bentley et al.
British journal of pharmacology, 126(7), 1537-1542 (1999-05-14)
1. The present study examined the effects of the selective 5-HT6 receptor antagonist 4-amino-N-(2, 6 bis-methylamino-pyrimidin-4-yl)-benzene sulphonamide (Ro 04-6790) on locomotor activity and unconditioned behaviour in male Sprague Dawley rats (230-300 g). 2. In non-quantified behavioural observations, animals treated with
Bofan Yu et al.
Cell cycle (Georgetown, Tex.), 18(20), 2641-2650 (2019-08-15)
Noncoding RNAs play important roles in the progression of malignant tumors, including triple negative breast cancer (TNBC). Accumulating evidence supported the involvement of the oncogenic MUC1 in tumor metastasis. Our study aimed to explore the roles of miR-140-5p and MUC1
A J Sleight et al.
British journal of pharmacology, 124(3), 556-562 (1998-07-01)
1. This study describes the in vitro characterization of two potent and selective 5-HT6 receptor antagonists at the rat and human recombinant 5-HT6 receptor. 2. In binding assays with [3H]-LSD, 4-amino-N-(2,6 bis-methylamino-pyrimidin-4-yl)-benzene sulphonamide (Ro 04-6790) and 4-amino-N-(2,6 bis-methylamino-pyridin-4-yl)-benzene sulphonamide (Ro

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