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生物来源
mouse
质量水平
重组
expressed in E. coli
方案
≥98% (SDS-PAGE)
表单
lyophilized powder
效能
10.0-25.0 ng/mL ED50
包装
pkg of 10 μg
储存条件
avoid repeated freeze/thaw cycles
技术
cell culture | mammalian: suitable
杂质
<0.1 ng/mg
<1 EU/μg
颜色
white
UniProt登记号
储存温度
−20°C
基因信息
mouse ... Tnfsf11(21943)
相关类别
一般描述
应用
RANK配体的功能包括诱 c-jun N末端激酶的活化、增强T细胞生长和破骨细胞生成的树突细胞功能诱导，以及淋巴结器官发生。RANK 配体的细胞表面信号传导受体是RANK，其在信号转导过程中的经受受体聚集。
小鼠 RANK 配体已用于可视化分化的破骨细胞，并刺激破骨细胞分化。[3]
生化/生理作用
外形
从 0.2 μm 过滤的5mM 磷酸钠，pH 7.6和75mM NaCl的溶液中冻干。
分析说明
生物活性由其诱导 RAW 264.7的破骨细胞分化的能力决定。该效果的预期 ED50 为≤10ng/ml。
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Ningning Jiang et al.
Biological trace element research, 193(1), 226-233 (2019-03-17)
Fluoride accumulates and is toxic to bones. Clinical bone lesions occur in a phased manner, being less severe early in the natural course of skeletal fluorosis. Previous research rarely focused on osteocyte, osteoclast, and osteoblast at the same time, although
p21-/- mice exhibit enhanced bone regeneration after injury
Priyantha Premnath
BMC Musculoskelet. Disord. (2017)
RANKL employs distinct binding modes to engage RANK and the OPG decoy receptor
Christopher A
Structure (2012)
Matrine prevents bone loss in ovariectomized mice by inhibiting RANKL-induced osteoclastogenesis
Xiao Chen
Faseb Journal (2017)
Elizabeth Rendina-Ruedy et al.
Journal of bone and mineral metabolism, 34(4), 380-394 (2015-06-11)
Skeletal fractures are considered a chronic complication of type 2 diabetes mellitus (T2DM), but the etiology of compromised bone quality that develops over time remains uncertain. This study investigated the concurrent alterations in metabolic and skeletal changes in two mouse
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