R0395

Rapamycin

from Streptomyces hygroscopicus, ≥95% (HPLC), powder, mTOR inhibitor

• 别名: AY 22989, 西罗莫司, 雷帕霉素
• 经验公式（希尔记法）: C₅₁H₇₉NO₁₃
• CAS号: 53123-88-9
• 分子量: 914.17
• MDL號碼: MFCD00867594
• 分類程式碼代碼: 12352200
• PubChem物質ID: 57654583
• NACRES: NA.77

属性

• product name: Rapamycin 来源于吸水链霉菌, ≥95% (HPLC), powder
• 品質等級: 300
• 化驗: ≥95% (HPLC)
• 形狀: powder
• 顏色: off-white
• 溶解度: ethanol: 2 mM; DMSO: soluble
• 抗生素活性譜: fungi; yeast
• 作用方式: enzyme | inhibits; protein synthesis | interferes
• 儲存溫度: −20°C
• SMILES 字串: CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC
• InChI: 1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
• InChI 密鑰: QFJCIRLUMZQUOT-HPLJOQBZSA-N
• 基因資訊: human ... FKBP1A(2280)

说明

一般說明

化学结构：大环内酯

Rapamycin is derived from Streptomyces hygroscopicus . It can inhibit viral replication. This natural anti-fungal antibiotic is a proven anti-aging agent. Rapamycin significantly inhibits mTORC1 regardless of age. It suppresses protein kinase C activity and enhances ion transport in A6 cells. It also suppresses the immune response in membrane and cytosolic preparations. Additionally, it has specific effects on the translation of endogenous mRNAs and inhibits the translation of 5′TOP mRNAs by blocking p70s6k activation in the signaling pathway. Rapamycin exhibits antineoplastic properties.

應用

Rapamycin from Streptomyces hygroscopicus has been used:

•  to treat BV2 cells or BV2-LC3 cells for autophagy assay
• as an autophagy activator in the bone marrow mesenchymal stem cells (BM-MSCs) transfected with lentivirus carrier of small interfering RNA for FOXO3 (siFOXO3) to study the effects of Forkhead Box O3 (FOXO3) on the autophagy of BM-MSCs
• to pre-incubate villi to inhibit the mammalian target of rapamycin complex 1 (mTORC1) signaling

生化／生理作用

一种与雷帕霉素(mTOR)分子靶点结合并抑制其作用的大环三烯抗生素。 它与FKBP12形成复合物，结合并抑制雷帕霉素(mTOR)的分子靶点。 雷帕霉素是一种有效的免疫抑制剂，并具有抗癌活性。

特點和優勢

《受体分类和信号转导》手册的 PKB/Akt 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

其他說明

保持容器密封，存放在干燥，通风良好的地方。保持干燥

安全信息

• 象形圖: GHS08
• 訊號詞: Warning
• 危險聲明: H351,H361fd
• 防範說明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危險分類: Carc. 2 - Repr. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)