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Merck

Q3638

Sigma-Aldrich

喹硫平 半富马酸盐

≥98% (HPLC)

别名:

2-[2-(4-二苯并[b,f] [1,4]硫氮杂-11-基-1-哌嗪基)乙氧基]乙醇半富马酸盐, 喹硫平富马酸盐

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10 MG
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10 MG
$103.00
50 MG
$409.00

About This Item

经验公式(希尔记法):
C21H25N3O2S · 0.5C4H4O4
分子量:
441.54
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

$103.00


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品質等級

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to off-white

溶解度

DMSO: >10 mg/mL

起源

AstraZeneca

儲存溫度

2-8°C

SMILES 字串

OC(=O)\C=C\C(O)=O.OCCOCCN1CCN(CC1)C2=Nc3ccccc3Sc4ccccc24.OCCOCCN5CCN(CC5)C6=Nc7ccccc7Sc8ccccc68

InChI

1S/2C21H25N3O2S.C4H4O4/c2*25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21;5-3(6)1-2-4(7)8/h2*1-8,25H,9-16H2;1-2H,(H,5,6)(H,7,8)/b;;2-1+

InChI 密鑰

ZTHJULTYCAQOIJ-WXXKFALUSA-N

基因資訊

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相关类别

一般說明

喹硫平是一种二苯并硫氮杂卓衍生物[1],也称为舍罗库尔和氯马斯汀。[2]

應用

喹硫平半富马酸盐已被用作β-抑制蛋白2 突变体T205M 募集的拮抗剂。[3]

生化/生理作用

喹硫平促进少突胶质细胞的体外形成。[2]它用于治疗抑郁症。[1]
喹硫平半富马酸盐是一种联合血清素(5HT2)和多巴胺(D2)受体拮抗剂。
喹硫平半富马酸盐是一种非典型抗精神病药,一种联合血清素(5HT2)和多巴胺(D2)受体拮抗剂。

特點和優勢

《受体分类和信号转导》手册的多巴胺受体页有该化合物的介绍。想要浏览手册的其他页面, 请单击此处
该化合物由AstraZeneca开发。要浏览其他药物开发化合物和批准的药物/候选药物列表,单击此处

象形圖

Exclamation markEnvironment

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Aquatic Acute 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Meng He et al.
Frontiers in aging neuroscience, 14, 847561-847561 (2022-05-27)
Emerging data indicate that antipsychotic treatment causes brain volume loss and astrocyte death, but the mechanisms remain elusive. Pyroptosis, inflammatory cell death characterized by the formation of inflammatory bodies, increased expression of nod-like receptor proteins (NLRPs) such as NLRP3, and
Preparation of rat oligodendrocyte progenitor cultures and quantification of oligodendrogenesis using dual-infrared fluorescence scanning
Schott JT, et al.
Journal of Visualized Experiments, 108, e53764-e53764 (2016)
Marc F Goldstein et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 97(6), 717-730 (2007-01-05)
To review and compare previously reported cases of selective IgM immunodeficiency (SIgMID) with the largest adult cohort obtained from a retrospective analysis of an allergy and immunology practice. Publications were selected from the English-only PubMed database (1966-2005) using the following
Ying-Ying He et al.
Peptides, 29(10), 1692-1699 (2008-06-28)
Snake venom Kunitz/BPTI members are good tools for understanding of structure-functional relationship between serine proteases and their inhibitors. A novel dual Kunitz/BPTI serine proteinase inhibitor named OH-TCI (trypsin- and chymotrypsin-dual inhibitor from Ophiophagus hannah) was isolated from king cobra venom
María E Terrón-Díaz et al.
The Journal of biological chemistry, 294(50), 19279-19291 (2019-11-05)
The D2 dopamine receptor and the serotonin 5-hydroxytryptamine 2A receptor (5-HT2A) are closely-related G-protein-coupled receptors (GPCRs) from the class A bioamine subfamily. Despite structural similarity, they respond to distinct ligands through distinct downstream pathways, whose dysregulation is linked to depression

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