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Merck

PZ0016

Sigma-Aldrich

多非利特

≥98% (HPLC), powder, hERG channel blocker

别名:

N-[4-[2-[甲基[2-[4-[(甲磺酰基)氨基]苯氧基]乙基]氨基]乙基]苯基]甲磺酰胺, UK-68798

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About This Item

经验公式(希尔记法):
C19H27N3O5S2
分子量:
441.56
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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产品名称

多非利特, ≥98% (HPLC)

方案

≥98% (HPLC)

表单

powder

颜色

white to off-white

溶解性

DMSO: >20 mg/mL

储存温度

room temp

SMILES字符串

CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc2ccc(NS(C)(=O)=O)cc2

InChI

1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3

InChI key

IXTMWRCNAAVVAI-UHFFFAOYSA-N

基因信息

human ... KCNH2(3757)

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生化/生理作用

多非利特是一种III类抗心律不齐和 hERG 通道阻滞剂。多非利特可选择地阻止延迟整流钾离子流 (Ikr)的快速成分。

特点和优势

该化合物在受体分类和信号转导手册的钾通道页面上有重点介绍。想要浏览手册的其他页面, 请单击此处

象形图

Health hazardEnvironment

警示用语:

Danger

危险声明

危险分类

Aquatic Chronic 2 - Repr. 1B - STOT RE 2

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Hanne Elming et al.
Expert opinion on pharmacotherapy, 4(6), 973-985 (2003-06-05)
Atrial fibrillation (AF) is the most common cardiac arrhythmia. Mortality, and especially morbidity caused by AF, are major and growing health problems in the western world. AF is strongly associated with arterial hypertension, congestive heart failure, valvular heart disease, ischaemic
S Durdagi et al.
Current medicinal chemistry, 18(17), 2601-2611 (2011-05-17)
The binding of various molecules to integral membrane proteins with optimal affinity and specificity is central to normal function of cell. While membrane proteins represent about one third of the whole cell proteome, they are a majority of common drug
Albert Dunnink et al.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 14(3), 431-436 (2011-09-29)
A number of predisposing factors have been suggested to be contributing to drug-induced torsade de pointes (TdP) arrhythmias: short-long-short (SLS) sequence, bradycardia, timing of drug administration, anaesthesia, ventricular remodelling, and altered ventricular activation due to ventricular ectopic beats (SLS) or
Cardiovascular drugs. Dofetilide.
J P Mounsey et al.
Circulation, 102(21), 2665-2670 (2000-11-22)
Amanda S Wilsey et al.
Comparative medicine, 71(2), 133-140 (2021-04-06)
Successful implementation of automated blood sampling (ABS) into a telemetry instrumented canine cardiovascular model provides simultaneous cardiovascular assessment of novel compounds while collecting multiple blood samples for analysis of drug level, cytokines, and biomarkers. Purpose-bred male Beagle dogs (n =

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