PRS4053

Anti-VISA (ab1) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 别名: Anti-CARD adapter inducing interferon-beta, Anti-MAVS, Anti-Mmitochondrial antiviral signaling protein, Anti-Virus-induced signaling adapter
• UNSPSC代码: 12352203
• NACRES: NA.41

属性

• 生物来源: rabbit
• 质量水平: 100
• 偶联物: unconjugated
• 抗体形式: affinity isolated antibody
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 表单: buffered aqueous solution
• 种属反应性: mouse, human, rat
• 技术: immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• UniProt登记号: Q7Z434
• 运输: dry ice
• 储存温度: −20°C
• 靶向翻译后修饰: unmodified
• 基因信息: human ... MAVS(57506)

说明

一般描述

VISA (virus-induced signalling adaptor) is also designated as MAVS (mitochondrial antiviral signalling protein). It has 540 amino acids and three main domains such as N-terminal caspase recruitment and activation domain (CARD), an internal proline-rich region and a C-terminal transmembrane (TM) domain. It is mapped to chromosome 20p13. It is intermediately expressed in all tissues and brain regions except in fetal brain.

免疫原

a 13 amino acid peptide from near the amino-terminus of human VISA.

生化/生理作用

VISA (virus-induced signalling adaptor) serves as an adaptor molecule for retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs). It activates intracellular signaling cascades, that leads to nuclear translocation of the transcription factors- IRF3 (interferon regulatory factor 3), IRF7 (interferon regulatory factor 7), and NF-κB (Nuclear factor-κB). It also helps in the formation of type I interferons (IFN-I) and proinflammatory cytokines.

联系

The action of this antibody can be blocked using blocking peptide SBP4053.

外形

Solution in phosphate buffered saline containing 0.02% sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 2
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable