PRS3985
Anti-Nicastrin (ab2) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-APH-2, Anti-Anterior pharynx defective 2, Anti-Nicastrin
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所有图片(3)
About This Item
共軛:
unconjugated
application:
ELISA (i)
IF
IHC
WB
IF
IHC
WB
無性繁殖:
polyclonal
物種活性:
human, rat, mouse
citations:
3
技術:
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
价格与库存信息目前不能提供
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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
human, rat, mouse
技術
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... NCSTN(23385)
一般說明
Nicastrin (NCSTN) is a transmembrane glycoprotein, that is located on chromosome 1q23.
免疫原
a 18 amino acid peptide from near the center of human Nicastrin.
應用
Anti-Nicastrin has been used in western blotting.
生化/生理作用
Nicastrin (NCSTN) helps in the assembly of γ-secretase complex. It is associated with Alzheimer′s disease.
聯結
The action of this antibody can be blocked using blocking peptide SBP3985.
外觀
Solution in phosphate buffered saline containing 0.02% sodium azide
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
WGK 2
閃點(°F)
Not applicable
閃點(°C)
Not applicable
The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample
Dermaut B, et al.
American Journal of Human Genetics, 70(6), 1568-1574 (2002)
Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
Kuzuya A, et al.
BMC Biology, 14:25 (2016)
Akira Kuzuya et al.
BMC biology, 14, 25-25 (2016-04-03)
Synaptic loss strongly correlates with memory deterioration. Local accumulation of amyloid β (Aβ) peptide, and neurotoxic Aβ42 in particular, due to abnormal neuronal activity may underlie synaptic dysfunction, neurodegeneration, and memory impairments. To gain an insight into molecular events underlying
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