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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 10 kDa
种属反应性
human
技术
microarray: suitable
western blot: 3-6 μg/mL using whole extract of human kidney 293 cells expressing human Pen-2
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... PSENEN(55851)
mouse ... Psen2(19165)
一般描述
Presenilin enhancer γ-secretase subunit (Pen-2/ PSENEN) gene, with four exons spanning 1.4 kb, is mapped to human chromosome 19q13.12. Pen-2 is an integral membrane protein with 101 amino acids. The protein is characterized with two transmembrane domains and a cytosolic loop domain, with the C- and N-termini facing the lumen of the endoplasmic reticulum.
特异性
Anti-PEN2 antibody recognizes Pen-2 (10 kDa).
免疫原
synthetic peptide encoding amino acids 86-101 located at the C-terminus of human pen-2, conjugated to KLH. This sequence is identical in mouse pen-2.
应用
Anti-Pen-2 antibody produced in rabbit has been used in immunoblotting.
生化/生理作用
Pen-2 is a critical component of the presenilin (PS)1/γ-secretase and PS2/γsecretase complexes. siRNA interference mediated down regulation of pen-2 is due to reduced PS levels, impaired nicastrin (Nct) maturation and deficient γ secretase complex formation. Pen-2 preferentially interacts with PS1 and induce PS1 endoproteolysis. In addition, it also stabilizes PS fragment heterodimer within the γ-secretase complex subsequent to PS endoproteolysis. PEN-2 plays a vital role in γ-secretase complex maturation in the absence of PS endoproteolysis. Mutation in the PEN-2 gene leads to the development of familial comedones syndrome.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
储存及稳定性
For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the $\gamma$-secretase complex
Prokop S, et al.
The Journal of Biological Chemistry, 279(22), 23255-23261 (2004)
A frameshift mutation in PEN-2 causes familial comedones syndrome
Panmontha W, et al.
Dermatology (Basel, Switzerland), 231(1), 77-81 (2015)
Dopamine D2 receptor and $\beta$-arrestin 2 mediate Amyloid-$\beta$ elevation induced by anti-parkinson?s disease drugs, levodopa and piribedil, in neuronal cells
Lu J, et al.
PLoS ONE, 12(3), e0173240-e0173240 (2017)
Membrane topology of $\gamma$-secretase component PEN-2
Crystal AS, et al.
The Journal of biological chemistry, 278(22), 20117-20123 (2003)
PEN-2 is an integral component of the $\gamma$-secretase complex required for coordinated expression of presenilin and nicastrin
Steiner H, et al.
The Journal of biological chemistry, 277(42), 39062-39065 (2002)
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