P4670

普罗帕酮 盐酸盐

• 别名: 1-[2-(2-Hydroxy-3-(propylamino)propoxy)phenyl]-3-phenyl-1-propanone hydrochloride
• 经验公式（希尔记法）: C₂₁H₂₇NO₃ · HCl
• CAS号: 34183-22-7
• 分子量: 377.90
• EC 号: 251-867-9
• MDL编号: MFCD00079243
• UNSPSC代码: 41116107
• PubChem化学物质编号: 24278636
• NACRES: NA.77

属性

• 表单: powder
• 创始人: Abbott
• 储存温度: 2-8°C
• SMILES字符串: Cl[H].CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2
• InChI: 1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
• InChI key: XWIHRGFIPXWGEF-UHFFFAOYSA-N
• 基因信息: human ... ABCB1(5243) , ADRB1(153) , ADRB2(154) , ADRB3(155) , CYP1A2(1544) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

说明

一般描述

Propafenone hydrochloride is a calcium antagonist.[1] It functions as a Na⁺ and K⁺ channel blocker.[2] It might be used to treat patients with systemic hypertension.[3] Propafenone hydrochloride is associated with bradycardia and bronchospasms. It is metabolized in the liver.[4] Propafenone hydrochloride is used to treat ventricular arrhythmias.[2]

应用

Propafenone hydrochloride has been used in the isolation of cardiomyocytes.[5]

生化/生理作用

Blocks hKv1.5 and ATP-sensitive K⁺ channels; class 1C antiarrhythmic agent that is also an antagonist at β adrenergic receptors.

特点和优势

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全信息

• 象形图: GHS07
• 警示用语：: Warning
• 危险声明: H302
• 预防措施声明: P264 - P270 - P301 + P312 - P501
• 危险分类: Acute Tox. 4 Oral
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3