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Merck

P4484

Sigma-Aldrich

Purvalanol A

≥98% (HPLC), powder

别名:

2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine, NG-60

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About This Item

经验公式(希尔记法):
C19H25ClN6O
分子量:
388.89
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

溶解度

methylene chloride: 50 mg/mL

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c3ncn(C(C)C)c3n1

InChI

1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1

InChI 密鑰

PMXCMJLOPOFPBT-HNNXBMFYSA-N

生化/生理作用

Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor.
Purvalanol A is found to inhibit ABCG2 (ATP-binding cassette G2) transporter in vitro.[1] It is also known to attenuate cellular Src kinase action and induce cell cycle arrest at the G2 to M phase transition.[2]

特點和優勢

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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