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![腺苷5′-[γ-硫代]三磷酸盐 四锂盐 ≥75% (HPLC), powder](/deepweb/assets/sigmaaldrich/product/structures/319/398/e29221c2-3649-455b-bd33-583bb017ec7d/640/e29221c2-3649-455b-bd33-583bb017ec7d.png)
生物来源
Streptomyces platensis
方案
≥90% (HPLC)
表单
solid
颜色
white to beige
溶解性
DMSO: 1 mg/mL, clear, colorless
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
作用机制
enzyme | inhibits
储存温度
−20°C
SMILES字符串
O=C1C=C[C@]2(C[H])[C@H]3CC[C@@](O3)([H])C2C1CCC(CNC4=C(O)C=CC(C(O)=O)=C4O)=O
InChI
1S/C22H25NO7/c1-22-9-8-14(25)12(18(22)16-6-7-17(22)30-16)3-2-11(24)10-23-19-15(26)5-4-13(20(19)27)21(28)29/h4-5,8-9,12,16-18,23,26-27H,2-3,6-7,10H2,1H3,(H,28,29)/t12?,16-,17+,18?,22+/m0/s1
InChI key
IGBNLKVUOHQLTO-MBQNLBDGSA-N
应用
Platensimycin (PTM) is a broad-spectrum antibiotic produced by LStreptomyces platensis. Platensimycin is used to inhibit lipid biosynthesis. It is used in diabetes research and to study the potential treatment of metabolic disorders.
生化/生理作用
Demonstrates no cross-resistance to other antibiotic-resistant bacteria, including MRSA (methicillin-resistant Staphylococcus aureus).
Mode of action: Selectively inhibits lipid biosynthesis by targeting FabF/B within the fatty acid synthesis pathway.
Antimicrobial spectrum: Gram-positive bacteria.
Mode of action: Selectively inhibits lipid biosynthesis by targeting FabF/B within the fatty acid synthesis pathway.
Antimicrobial spectrum: Gram-positive bacteria.
Platensimycin selectively inhibits the elongation-condensing enzymes FabF/B of the fatty acid biosynthesis pathway in bacteria. PTM is a potent and highly selective inhibitor of mammalian fatty acid synthase. Platensimycin specifically inhibits fatty acid synthesis but not sterol synthesis in rat primary hepatocytes. It is thought that the thiol group of FabF Cys163 may be activated through the dipole moment of helix N-α-3 which lowers the pKa. It does not demonstrate cross-resistance to other antibiotic-resistant bacteria, including MRSA (methicillin-resistant Staphylococcus aureus). It is active against Gram-positive bacteria.
Selectively inhibits lipid biosynthesis by targeting FabF/B within the fatty acid synthesis pathway.
其他说明
Keep container tightly closed in a dry and well-ventilated place.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Allen C Price et al.
Journal of bacteriology, 185(14), 4136-4143 (2003-07-03)
The beta-ketoacyl-acyl carrier protein synthases are members of the thiolase superfamily and are key regulators of bacterial fatty acid synthesis. As essential components of the bacterial lipid metabolic pathway, they are an attractive target for antibacterial drug discovery. We have
Szu-Yi Hsu et al.
ACS synthetic biology, 8(10), 2397-2403 (2019-09-06)
Serofendic acid is a natural neuroprotective molecule found in fetal calf serum. It is able to protect neurons against mechanisms of cell death associated with neurodegenerative disease. Because only trace quantities are present in fetal calf serum and complete chemical
Makoto Hibi et al.
Communications biology, 4(1), 16-16 (2021-01-06)
The high-valent iron-oxo species formed in the non-heme diiron enzymes have high oxidative reactivity and catalyze difficult chemical reactions. Although the hydroxylation of inert methyl groups is an industrially promising reaction, utilizing non-heme diiron enzymes as such a biocatalyst has
Ian Rowe et al.
International journal of molecular sciences, 16(8), 17909-17932 (2015-08-08)
Membrane permeability is a desired property in drug design, but there have been difficulties in quantifying the direct drug partitioning into native membranes. Platensimycin (PL) is a new promising antibiotic whose biosynthetic production is costly. Six dialkylamine analogs of PL
Kenzie A Clark et al.
Journal of the American Chemical Society, 141(27), 10610-10615 (2019-06-28)
The biosynthetic pathways of microbial natural products provide a rich source of novel enzyme-catalyzed transformations. Using a new bioinformatic search strategy, we recently identified an abundance of gene clusters for ribosomally synthesized and post-translationally modified peptides (RiPPs) that contain at
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