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product name
N-(3-氧代癸酰基)-L-高丝氨酸内酯,
化驗
≥98% (TLC)
形狀
powder
顏色
white
應用
cell analysis
運輸包裝
wet ice
儲存溫度
−20°C
SMILES 字串
CCCCCCCC(=O)CC(=O)N[C@H]1CCOC1=O
InChI
1S/C14H23NO4/c1-2-3-4-5-6-7-11(16)10-13(17)15-12-8-9-19-14(12)18/h12H,2-10H2,1H3,(H,15,17)/t12-/m0/s1
InChI 密鑰
KYGIKEQVUKTKRR-LBPRGKRZSA-N
一般說明
N-（3-氧代癸酰基）高丝氨酸-L-内酯（3-氧代-C10-HSL）属于高丝氨酸内酯，其包括： N-辛酰基-高丝氨酸内酯（N-C8-HSL）、N-（3-氧代十二烷酰基）高丝氨酸-L-内酯（3-氧代-C12 HSL）、N-（3-氧代十四烷酰基）-L-高丝氨酸内酯（3-oxo-C14-HSL）、N-（3-羟基癸酰基）-L-高丝氨酸内酯以及N-（3-羟基辛酰基）-L-高丝氨酸内酯。
應用
N-（3-氧代癸酰基）高丝氨酸-L-内酯（3-氧代-C10-HSL）可用于研究细菌群体感应调节涉及的信号传导。
生化／生理作用
酰化高丝氨酸内酯被用作恶臭假单胞菌、小肠结肠炎耶尔森菌和其他革兰氏阴性细菌的群体信号传导的自诱导剂。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Rumana Rashid et al.
Microbes and environments, 26(2), 144-148 (2011-04-20)
N-Acylhomoserine lactones (AHLs) are used as quorum-sensing signaling molecules by many Gram-negative bacteria. Here, 413 bacterial strains were obtained from the roots of potato plants and screened for AHL-degrading bacteria using Chromobacterium violaceum reporter strains. Sixty one isolates degraded N-hexanoyl-L-homoserine
John F Teiber et al.
Methods in molecular biology (Clifton, N.J.), 692, 291-298 (2010-10-30)
Mammalian paraoxonases (PONs) are a unique, highly conserved family of calcium-dependent esterases consisting of PON1, PON2, and PON3. The PONs can hydrolyze the lactone ring of a range of N-acyl-L: -homoserine lactone (AHL) quorum sensing signaling molecules, rendering them inactive.
Bijay K Khajanchi et al.
Infection and immunity, 79(7), 2646-2657 (2011-05-04)
Aeromonas hydrophila leads to both intestinal and extraintestinal infections in animals and humans, and the underlying mechanisms leading to mortality are largely unknown. By using a septicemic mouse model of infection, we showed that animals challenged with A. hydrophila die
Mair E A Churchill et al.
Methods in molecular biology (Clifton, N.J.), 692, 159-171 (2010-10-30)
Quorum sensing plays a central role in regulating many community-derived symbiotic and pathogenic relationships of bacteria, and as such has attracted much attention in recent years. Acyl-homoserine lactones (AHLs) are important signaling molecules in the quorum sensing gene-regulatory processes found
Manabu Horikawa et al.
Bioorganic & medicinal chemistry letters, 16(8), 2130-2133 (2006-02-08)
The synthesis of the analogs of N-3-oxododecanoyl-L-homoserine lactone (1) and their structure-activity relationship for the apoptotic induction in macrophages, P388D1 cells, are described. It was revealed that the position of the oxo group in the acyl side chain in addition
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