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MAK184

Sigma-Aldrich

琥珀酸检测试剂盒（比色法）

Sufficient for 100 Colorimetric tests

别名:

琥珀酸检测试剂盒

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About This Item

EC 号:
205-778-7
UNSPSC代码:
12161503
NACRES:
NA.84

应用

cosmetics
food and beverages

检测方法

colorimetric

相关疾病

cardiovascular diseases; immunological diseases

储存温度

−20°C

一般描述

琥珀酸（琥珀酸）是柠檬酸循环中间体，在将电子传递到线粒体电子传递链中起作用。[1][2]它还在先天免疫信号传导中起作用，并在炎症期间诱导 IL-1β 产生。琥珀酸盐经常用于治疗高血压。[3]琥珀酸盐测量可用于研究其代谢、免疫和治疗活性。

应用

琥珀酸检测试剂盒（比色法）已用于测量琥珀酸的浓度。[4][5]

适用性

适于测定不同生物样品内的琥珀酸，如细胞和组织培养上清液以及酒类等液态样品。

原理

琥珀酸检测试剂盒（比色法）是一种高灵敏度检测法，用于测定各种样品中的琥珀酸盐水平（范围为 2-10 nmole/孔）。琥珀酸浓度通过偶联酶反应测定，其产生与存在的琥珀酸盐成比例的比色（450nm）产物。

仅试剂盒组分

产品编号
说明
  • Succinate Assay Buffer
  • Succinate Converter
  • Succinate Enzyme Mix
  • Succinate Substrate Mix
  • Succinate Developer
  • Succinate Standard

象形图

Health hazardCorrosion
GHS08,GHS05

警示用语：

Danger

危险声明

H314,H334

危险分类

Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B

储存分类代码

8A - Combustible corrosive hazardous materials

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
8G27K06490
7A21K06490
4C08K06490
4A18K06490
3B02K06490

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Mengdi Zhang et al.
Cell death discovery, 8(1), 138-138 (2022-03-31)
Hypoxia causes neonatal neuronal damage. However, the underlying mechanism remains unclear. This study aimed to explore the changes in succinate levels and identify the mechanisms underlying their contribution to hypoxia-induced damage in newborn mice. The neonatal C57BL/6J mouse hypoxia model
Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis.
Tretter L, et al.
Biochimica et Biophysica Acta - Bioenergetics, 1857(8), 1086-1101 (2016)
Electron Transport and Oxidative Phosphorylation
Lodish H, et al.
Molecular Cell Biology (2000)
VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism.
Li J, et al.
Nature Communications, 8(1), 1322-1322 (2017)
DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism.
Shen J, et al.
JCI insight, 2(12) (2017)
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Questions

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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