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Merck
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M6545

Sigma-Aldrich

米托蒽醌 二盐酸盐

≥97% (HPLC)

别名:

1,4-二羟基-5,8-双-[[2-[（2-羟乙基）氨基] 乙基] 氨基]-9,10-蒽二酮 二盐酸盐

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About This Item

经验公式（希尔记法）:
C22H28N4O6 · 2HCl
CAS号:
70476-82-3
分子量:
517.40
EC號碼:
274-619-1
MDL號碼:
MFCD00242943
分類程式碼代碼:
12352005
PubChem物質ID:
24278562
NACRES:
NA.25

化驗

≥97% (HPLC)

SMILES 字串

Cl[H].Cl[H].OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12

InChI

1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H

InChI 密鑰

ZAHQPTJLOCWVPG-UHFFFAOYSA-N

基因資訊

human ... TOP2A(7153)

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應用

盐酸米托蒽醌已用于：
  • 诱导细胞表达钙网蛋白
  • 作为遗传毒素剂
  • 作为拓扑异构酶抑制剂

生化／生理作用

米托蒽醌是一种细胞抑制性蒽二酮，可嵌入 DNA 中，通过稳定拓扑异构酶 II 与 DNA 的可裂解复合物，增加双链断裂的发生率。米托蒽醌还表现出广泛的免疫抑制活性，抑制各类淋巴细胞增殖并诱导抗原提呈 T 细胞凋亡。它在临床上用作抗白血病和实体瘤的化疗药物以及多发性硬化症的免疫系统调节剂。

象形圖

Health hazard
GHS08

訊號詞

Danger

危險聲明

H340,H360

危險分類

Muta. 1B - Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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