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Merck
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文件

M4765

Sigma-Aldrich

N-甲氧基琥珀酰-Ala-Ala-Pro-Val 对硝基苯胺

elastase substrate, chromogenic, ≥98% (HPLC), powder

别名:

N-（甲氧基琥珀酰基）-L-丙氨酰-L-丙氨酰-L-脯氨酰-L-缬氨酸4-硝基苯胺, N-（甲氧基琥珀酰基）-Ala-Ala-Pro-Val 4-硝基苯胺

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About This Item

经验公式（希尔记法）:
C27H38N6O9
CAS号:
70967-90-7
分子量:
590.63
Beilstein:
6266359
MDL號碼:
MFCD00077137
分類程式碼代碼:
12352204
PubChem物質ID:
24896943
NACRES:
NA.32

product name

N-甲氧基琥珀酰-Ala-Ala-Pro-Val 对硝基苯胺, elastase substrate

化驗

≥98% (HPLC)

形狀

powder

溶解度

DMF: soluble 25 mg/mL, clear, colorless to light yellow

儲存溫度

−20°C

SMILES 字串

[H][C@]1(CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CCC(=O)OC)C(=O)N[C@@H](C(C)C)C(=O)Nc2ccc(cc2)[N+]([O-])=O

InChI

1S/C27H38N6O9/c1-15(2)23(26(38)30-18-8-10-19(11-9-18)33(40)41)31-25(37)20-7-6-14-32(20)27(39)17(4)29-24(36)16(3)28-21(34)12-13-22(35)42-5/h8-11,15-17,20,23H,6-7,12-14H2,1-5H3,(H,28,34)(H,29,36)(H,30,38)(H,31,37)/t16-,17-,20-,23-/m0/s1

InChI 密鑰

VLVGCNNWNUERRZ-OSAZLGQLSA-N

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相关类别

應用

MeO-SucAAPVpNA已用于测量嗜中性粒细胞弹性蛋白酶活性：
  • 人和小鼠嗜中性粒细胞体外补充锌补充造成的结果
  • 确定老化嗜中性粒细胞的功能特性，以评估它们在促进肿瘤转移方面的作用
  • 确定伯尔硬胡桃（Sclerocarya birrea (A. Rich.)）的抗弹性蛋白酶作用Hochst

生化／生理作用

人类白细胞弹性蛋白酶 (HLE) 是一种丝氨酸蛋白酶，与炎症和组织退化相关。它是最具破坏性的蛋白酶之一，其在肺气肿进程中的作用得到了广泛研究。这种肽酶可被HLE及不同物种和细胞的其他弹性蛋白酶选择性水解。弹性蛋白酶样蛋白酶切割MeO-SucAPVVpNA对于肿瘤坏死因子-α (TNF-α)和白细胞介素-1α (IL-1α)诱导的血小板活化因子(PAF)合成至关重要。由于释放4-硝基苯胺，底物的酶促水解速率随着吸光度增加。通常在400 nm或更高波长处测量吸光度。

基底

人白细胞弹性蛋白酶的底物。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Anti-neutrophil cytoplasmic antibodies (ANCA) against proteinase 3 (PR3) are strongly associated with Wegener's granulomatosis (WG) and are thought to be involved in its pathogenesis. Levels of PR3-ANCA do not always correspond to clinical disease activity. To investigate the relationship between
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Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

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