跳转至内容
Merck
所有图片(1)

主要文件

查看所有文档

M3668

Sigma-Aldrich

Metergoline

别名:

N-CBZ-[(8β)-1,6-Dimethylergolin-8-yl]methylamine, [(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamic acid phenylmethyl ester

登录查看公司和协议定价

选择尺寸

500 MG
$194.00
5 G
$1,810.00

$194.00

请联系客服了解存货情况
获取大包装报价
所有图片(1)

选择尺寸

变更视图
500 MG
$194.00
5 G
$1,810.00

About This Item

经验公式（希尔记法）:
C25H29N3O2
CAS号:
17692-51-2
分子量:
403.52
EC 号:
241-686-3
MDL编号:
MFCD00153829
UNSPSC代码:
12352200
PubChem化学物质编号:
24278105
NACRES:
NA.77

$194.00

请联系客服了解存货情况
获取大包装报价

mp

148-150 °C (lit.)

溶解性

0.1 M HCl: 1.4 mg/mL
ethanol: 4 mg/mL
H2O: insoluble

储存温度

−20°C

SMILES字符串

[H][C@]2(CNC(=O)OCc1ccccc1)CN(C)[C@]3([H])Cc4cn(C)c5cccc(c45)[C@@]3([H])C2

InChI

1S/C25H29N3O2/c1-27-14-18(13-26-25(29)30-16-17-7-4-3-5-8-17)11-21-20-9-6-10-22-24(20)19(12-23(21)27)15-28(22)2/h3-10,15,18,21,23H,11-14,16H2,1-2H3,(H,26,29)/t18-,21+,23+/m0/s1

InChI key

WZHJKEUHNJHDLS-QTGUNEKASA-N

基因信息

human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR7(3363)
rat ... Htr7(65032)

正在寻找类似产品? 访问 产品对比指南

相关类别

应用

Metergoline has been used as a serotonin receptor antagonist:

  • to study its effects on astrocyte calcium signals evoked by whisker stimulation[1]
  • to study its effects on lipopolysaccharide-induced anorexia in rats[2]
  • to evaluate the non-specific binding by 5-HT1A receptor binding assays[3]

生化/生理作用

Metergoline is an ergot alkaloid[4] and a selective serotonin antagonist which blocks the 5-HT2A and 5-HT2C receptors with higher affinity.[5] It possesses antifungal activity against infection caused by Candida krusei.[6] Metergoline exhibits a therapeutic effect against premenstrual dysphoric disorder. It also exhibits antipyretic and analgesic activities.[7]

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302 + H312 + H332

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCL4038
BCCL9897
BCCL0669
BCCH9470
BCCG9869

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Boeun Lee et al.
Molecules (Basel, Switzerland), 26(11) (2021-06-03)
N-phenylpiperazine analogs can bind selectively to the D3 versus the D2 dopamine receptor subtype despite the fact that these two D2-like dopamine receptor subtypes exhibit substantial amino acid sequence homology. The binding for a number of these receptor subtype selective
Camila Marroni Roncon et al.
Planta medica, 77(3), 236-241 (2010-09-17)
The objective of this study was to investigate the effects of chronic administration of a semi-purified extract (Purified Extract A--PEA; 4, 8, or 16 mg/kg) of PAULLINIA CUPANA (guaraná) seeds on rats submitted to the elevated T-maze (ETM) model of
J David Glass et al.
The European journal of neuroscience, 31(6), 1117-1126 (2010-04-10)
Timing of the circadian clock of the suprachiasmatic nucleus (SCN) is regulated by photic and non-photic inputs. Of these, neuropeptide Y (NPY) signaling from the intergeniculate leaflet (IGL) to the SCN plays a prominent role. Although NPY is critical to
B K Smith et al.
The American journal of physiology, 277(3 Pt 2), R802-R811 (1999-09-14)
Systemic treatment with dexfenfluramine (dF), fluoxetine, or serotonin (5-hydroxytryptamine, 5-HT) recently was shown to suppress fat and occasionally protein but not carbohydrate intake in rats when a macronutrient selection paradigm was employed. These reports contrast with the prevailing literature, which
N J Beijerink et al.
Reproduction (Cambridge, England), 128(2), 181-188 (2004-07-29)
Dopamine agonists decrease plasma prolactin concentration and shorten the duration of anoestrus in the bitch. In order to determine whether this shortening results from decreased prolactin release or is due to another dopamine agonistic effect on the pulsatile release of
查看所有相关文献

Questions

Reviews

No rating value

Active Filters

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门