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Merck

L8912

Sigma-Aldrich

L-亮氨酸

98.5-101.0%, suitable for cell culture, non-animal source, meets EP, JP, USP testing specifications

别名:

(S)-亮氨酸, (S)-2-氨基-4-甲基戊酸

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10 MG
$68.70
25 G
$120.00
100 G
$236.00
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$1,470.00

$68.70


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10 MG
$68.70
25 G
$120.00
100 G
$236.00
1 KG
$1,470.00

About This Item

线性分子式:
(CH3)2CHCH2CH(NH2)CO2H
CAS号:
分子量:
131.17
Beilstein:
1721722
EC 号:
MDL编号:
UNSPSC代码:
12352209
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.26

$68.70


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产品名称

L-亮氨酸, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%

生物来源

non-animal source

质量水平

Agency

USP/NF
meets EP testing specifications
meets JP testing specifications
meets USP testing specifications

方案

98.5-101.0%

表单

powder

旋光性

[α]20/D 14.9 to 16.0°, c = 4 in 6 M HCl
[α]25/D 14.9 to 17.3 °, c = 4 in 6 M HCl

质量

meets EP, JP, USP testing specifications

技术

cell culture | mammalian: suitable

杂质

endotoxin, tested

颜色

white

mp

>300 °C (lit.)

溶解性

1 M HCl: 50 mg/mL

痕量阳离子

As: ≤1 ppm
Fe: ≤10 ppm
NH4+: <0.02%
heavy metals: ≤10 ppm

应用

peptide synthesis
pharmaceutical (small molecule)

官能团

amine
carboxylic acid

储存温度

room temp

SMILES字符串

CC(C)C[C@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1

InChI key

ROHFNLRQFUQHCH-YFKPBYRVSA-N

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一般描述

亮氨酸是一种非生糖必需氨基酸。它是一种支链氨基酸,是蛋白质的结构组分。[1]

应用

L-亮氨酸可用于:

  • 作为肥大剂来监测其对肌管的影响。[2]
  • 作为培养酵母的 PMG 培养基的组成部分。[3]
  • 用于骨骼肌细胞的肌管蛋白质合成分析。[4]
  • 研究其对肝脏脂质代谢的影响。[5]

生化/生理作用

亮氨酸在细胞内信号转导、基因转录和翻译中发挥作用。它通过激活胎盘细胞、骨骼肌和脂肪组织中雷帕霉素(mTOR)信号通路的哺乳动物靶点来促进蛋白质的合成。[6]亮氨酸抑制蛋白质降解,促进线粒体生物合成、葡萄糖代谢和脂肪酸氧化,为蛋白质合成提供能量。[1]

其他说明

如需了解生化试剂系列的更多信息,请填写此表
本品仅供实验室使用,不适用于药物、家庭或其他用途。

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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